Journal Article10.1080/09205063.2017.1394711
PCL and PCL-based materials in biomedical applications
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TL;DR: PCL is a polyester that has been widely used in tissue engineering field for its availability, relatively inexpensive price and suitability for modification, and it can be used under harsh mechanical, physical and chemical conditions without significant loss of its properties.
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Abstract: Biodegradable polymers have met with an increasing demand in medical usage over the last decades. One of such polymers is poly(e-caprolactone) (PCL), which is a polyester that has been widely used in tissue engineering field for its availability, relatively inexpensive price and suitability for modification. Its chemical and biological properties, physicochemical state, degradability and mechanical strength can be adjusted, and therefore, it can be used under harsh mechanical, physical and chemical conditions without significant loss of its properties. Degradation time of PCL is quite long, thus it is used mainly in the replacement of hard tissues in the body where healing also takes an extended period of time. It is also used at load-bearing tissues of the body by enhancing its stiffness. However, due to its tailorability, use of PCL is not restricted to one type of tissue and it can be extended to engineering of soft tissues by decreasing its molecular weight and degradation time. This review ou...
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Citations
Incorporation of graphene oxide into poly(ɛ-caprolactone) 3D printed fibrous scaffolds improves their antimicrobial properties.
Sofia F. Melo,Sara C. Neves,Andreia T. Pereira,I. Borges,Pedro L. Granja,Fernão D. Magalhães,Inês C. Gonçalves +6 more
TL;DR: The potential of GO-containing fibrous scaffolds to be used as biomaterials that hinder bacterial infection, while allowing human cells adhesion is demonstrated.
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Physical, Thermal, and Antibacterial Effects of Active Essential Oils with Potential for Biomedical Applications Loaded onto Cellulose Acetate/Polycaprolactone Wet-Spun Microfibers.
Helena P. Felgueiras,Natália C. Homem,Marta A. Teixeira,Ana Ribeiro,Joana C. Antunes,Maria Teresa Pessoa de Amorim +5 more
- 31 Jul 2020
TL;DR: Results indicate that CA/PCL microfibers loaded with EOs can be easily produced with increased antibacterial action, envisioning their use as scaffolding materials for the treatment of infections.
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Antibacterial Electrospun Polycaprolactone Nanofibers Reinforced by Halloysite Nanotubes for Tissue Engineering
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TL;DR: It was found that the nanofibers exhibited outstanding antibacterial properties and inhibited both Gram- and Gram+ (Staphylococcus aureus) bacteria and a significant enhancement of mechanical properties was achieved.
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References
•Book
Encyclopedia of polymer science and technology
Jacqueline I. Kroschwitz,Herman F. Mark +1 more
- 01 Jan 2003
TL;DR: In this article, the authors present a survey of the properties of polymers and their application in the field of chemical engineering, including the following: Coextrusion, Injection Molding, Flexible Packaging, Fibers, Polymer-Clay, and Plasticizers.
5.7K
Scaffolds in tissue engineering bone and cartilage.
TL;DR: Research on the tissue engineering of bone and cartilage from the polymeric scaffold point of view is reviews from a biodegradable and bioresorbable perspective.
5.3K
Biodegradable polymeric nanoparticles based drug delivery systems
TL;DR: The impact of nanoencapsulation of various disease related drugs on biodegradable nanoparticles such as PLGA, PLA, chitosan, gelatin, polycaprolactone and poly-alkyl-cyanoacrylates is highlighted.
3.6K
The return of a forgotten polymer—Polycaprolactone in the 21st century
TL;DR: Polycaprolactone (PCL) was used in the biomaterials field and a number of drug-delivery devices for up to 3-4 years.
3.5K
Biodegradable nanoparticles for drug and gene delivery to cells and tissue
Jayanth Panyam,Vinod Labhasetwar +1 more
TL;DR: Based on the above mechanism, various potential applications of nanoparticles for delivery of therapeutic agents to the cells and tissue are discussed.
3.5K