PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes.

TL;DR: The deubiquitinase USP7 is identified as an integral member of non-canonical PRC1.1 and is required for its stability and function, and its diverse functions are highlighted and linked to Polycomb-mediated epigenetic control.

TL;DR: It is demonstrated that the protein is required for female fertility, whereas its ablation brings to a global increase of H3K27me3 PRC2-associated mark in male germ cells with little consequences on male fertility.

TL;DR: Polycomb Proteins in Hematopoiesis and Hematologic Malignancie and how these proteins interact with each other and with the immune system is investigated.

TL;DR: Emerging evidence suggesting that the onset of puberty is controlled at the transcriptional level by interactive gene networks subjected to epigenetic regulation is discussed.

TL;DR: The Genomic Regions Enrichment of Annotations Tool (GREAT) is developed to analyze the functional significance of cis-regulatory regions identified by localized measurements of DNA binding events across an entire genome.

TL;DR: The wild-type and mutant segmentation patterns are consistent with an antero-posterior gradient in repressor concentration along the embryo and a proximo-distal gradient along the chromosome in the affinities for repressor of each gene's cis-regulatory element.

TL;DR: This work has uncovered a role for non-coding RNA in the recruitment of PRC2 to target genes, and expanded the perspectives on its function and regulation.

TL;DR: It is shown that PcG proteins directly repress a large cohort of developmental regulators in murine ES cells, the expression of which would otherwise promote differentiation, and dynamic repression of developmental pathways by Polycomb complexes may be required for maintaining ES cell pluripotency and plasticity during embryonic development.