PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes.
Zhonghua Gao,Jin Zhang,Roberto Bonasio,Francesco Strino,Ayana Sawai,Fabio Parisi,Yuval Kluger,Danny Reinberg +7 more
855
TL;DR: A comprehensive proteomic and genomic analysis uncovered six major groups of PRC1 complexes, each containing a distinct PCGF subunit, a RING1A/B ubiquitin ligase, and a unique set of associated polypeptides.
read more
About: This article is published in Molecular Cell. The article was published on 10 Feb 2012. and is currently open access.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
A genetic approach to the recruitment of PRC2 at the HoxD locus.
Patrick Schorderet,Nicolas Lonfat,Fabrice Darbellay,Patrick Tschopp,Sandra Gitto,Natalia Soshnikova,Denis Duboule,Denis Duboule +7 more
TL;DR: It is reported that various genomic re-arrangements of the gene cluster do not strongly affect PRC2 recruitment and that relatively small polycomb interacting sequences appear necessary and sufficient to confer polycomb recognition and targeting to ectopic loci.
Chromatin regulators in mammalian epidermis.
TL;DR: The epidermis is emerging as an ideal model system to characterize the functional roles of epigenetic mechanisms that orchestrate organogenesis and adult tissue homeostasis and repair.
38
mSWI/SNF promotes polycomb repression both directly and through genome-wide redistribution
Christopher M. Weber,Antonina Hafner,Simon M. G. Braun,Jacob G. Kirkland,Benjamin Z. Stanton,Benjamin Z. Stanton,Alistair N. Boettiger,Gerald R. Crabtree,Gerald R. Crabtree +8 more
TL;DR: It is reported that rapid BAF depletion redistributes both PRC1 and PRC2 complexes from highly occupied domains, like Hox clusters, to weakly occupied sites that are normally opposed by BAF, providing new mechanistic insight into the highly dynamic state of the Polycomb-Trithorax axis.
PRC1 preserves epidermal tissue integrity independently of PRC2
Idan Cohen,Dejian Zhao,Gopinathan K. Menon,Manabu Nakayama,Haruhiko Koseki,Deyou Zheng,Elena Ezhkova +6 more
TL;DR: A functional link between epigenetic regulation and skin diseases is demonstrated and it is shown that despite extensive genomic cobinding, PRC1 is essential for epidermal integrity, whereas PRC2 is dispensable.
Polycomb and trithorax opposition in development and disease.
TL;DR: The past, present, and future of the Polycomb group (PcG) and trxG chromatin modulators are outlined, which work together to coordinate the appropriate cellular developmental programs that allow for both embryonic stem cell self‐renewal and differentiation.
37
References
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
TL;DR: A procedure for preparing extracts from nuclei of human tissue culture cells that directs accurate transcription initiation in vitro from class II promoters, including tRNA and Ad 2 VA, is developed.
GREAT improves functional interpretation of cis-regulatory regions
Cory Y. McLean,Dave Bristor,Michael Hiller,Shoa L. Clarke,Bruce T. Schaar,Craig B. Lowe,Aaron M. Wenger,Gill Bejerano +7 more
TL;DR: The Genomic Regions Enrichment of Annotations Tool (GREAT) is developed to analyze the functional significance of cis-regulatory regions identified by localized measurements of DNA binding events across an entire genome.
A gene complex controlling segmentation in Drosophila.
TL;DR: The wild-type and mutant segmentation patterns are consistent with an antero-posterior gradient in repressor concentration along the embryo and a proximo-distal gradient along the chromosome in the affinities for repressor of each gene's cis-regulatory element.
The Polycomb complex PRC2 and its mark in life
Raphaël Margueron,Danny Reinberg +1 more
TL;DR: This work has uncovered a role for non-coding RNA in the recruitment of PRC2 to target genes, and expanded the perspectives on its function and regulation.
Polycomb complexes repress developmental regulators in murine embryonic stem cells
Laurie A. Boyer,Kathrin Plath,Kathrin Plath,Julia Zeitlinger,Tobias Brambrink,Lea Ann Medeiros,Tong Ihn Lee,Stuart S. Levine,Marius Wernig,Adriana Tajonar,Mridula K. Ray,George W. Bell,Arie P. Otte,Miguel Vidal,David K. Gifford,Richard A. Young,Rudolf Jaenisch +16 more
TL;DR: It is shown that PcG proteins directly repress a large cohort of developmental regulators in murine ES cells, the expression of which would otherwise promote differentiation, and dynamic repression of developmental pathways by Polycomb complexes may be required for maintaining ES cell pluripotency and plasticity during embryonic development.
2.7K