Pattern formation in the absence of cell proliferation: tissue-specific regulation of cell cycle progression by string (stg) during Drosophila eye development.
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TL;DR: In this article, the cdc25 phosphatase string (stg) has been proposed to contribute to the synchronization of retinal precursors anterior to the morphogenetic furrow by driving cells in G2 through mitosis and into a subsequent G1.
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About: This article is published in Developmental Biology. The article was published on 01 Sep 1999. and is currently open access. The article focuses on the topics: Mitosis & Cell fate determination.
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Citations
•Journal Article
Cyclin-dependent kinase inhibitors in the development of the central nervous system.
TL;DR: This review will attempt to provide an update of what is known about the cdkis in specific regions of the CNS across the phyla, including Caenorhabditis elegans, Xenopus laevis, Drosophila melanogaster, Mus musculus, and Rattus rattus and discuss the relation ofcdkis with cyclin-cdk complexes and their substrate, the pRb.
107
My what big eyes you have: How the Drosophila retina grows
TL;DR: This review will focus on how growth of the retina is controlled by the genes and pathways that govern the specification of tissue fate, the division of the epithelium into dorsal‐ventral compartments, the initiation, and progression of the morphogenetic furrow and the second mitotic wave.
84
Lateral inhibition and neurogenesis: novel aspects in motion.
TL;DR: The emerging concept is that lateral inhibition during neurogenesis occurs in dynamic clusters of precursor and requires specific mechanisms to avoid distortions resulting from the interaction between neurogenic and non-neurogenic precursors.
Size matters: The contribution of cell proliferation to the progression of the specification Drosophila eye gene regulatory network
Gabriele Amore,Fernando Casares +1 more
TL;DR: This work presents a working model meant to illustrate how during a critical period, the second larval stage, changes in cells' proliferative pattern are coordinated with the initiation of the Retinal Determination (RD) gene program.
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smoothened, thickveins and the genetic control of cell cycle and cell fate in the developing Drosophila eye
Alysia D. Vrailas,Kevin Moses +1 more
TL;DR: It is concluded that both Hedgehog and Decapentaplegic pathways have several, but differing roles in furrow induction and cell fate and survival, but that neither directly affects cell type specification.
33
References
mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2
Karen Lundgren,Nancy C. Walworth,Robert Booher,Marlene Dembski,Marc W. Kirschner,David Beach +5 more
TL;DR: It is shown here that a related 66 kd kinase, called mik1, acts redundantly with wee1 in the negative regulation of cdc2 in S, both in strains undergoing mitotic lethality and in those that are viable owing to a compensating mutation within cDC2.
atonal is the proneural gene for Drosophila photoreceptors
TL;DR: It is found that photoreceptor formation requires the function of atonal at the morphogenetic furrow and that atonal is specifically required for R8 selection, and that photo-receptors are selected by two mechanisms: R8 by a proneural mechanism, and Rl–7 by local recruitment.
The TGFβ homolog dpp and the segment polarity gene hedgehog are required for propagation of a morphogenetic wave in the Drosophila retina
TL;DR: The results suggest that developing retinal cells drive the progression of morphogenesis utilizing the products of the hedgehog (hh) and decapentaplegic (dpp) genes.
The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae.
TL;DR: The data suggest that fzy function is required for normal cell cycle-regulated proteolysis that is necessary for successful progress through mitosis.
Hedgehog-dependent patterning in the Drosophila eye can occur in the absence of Dpp signaling.
Richard Burke,Konrad Basler +1 more
TL;DR: Analysis of somatic clones of cells lacking the Dpp receptors Punt or Tkv reveals that Dpp plays only a minor role in furrow progression and no critical role in subsequent ommatidial development.