Pathway to Totipotency: Lessons from Germ Cells
TL;DR: Common themes emerging from the study of germ cells in vertebrates and invertebrates are described, including transcriptional repression, chromatin remodeling, and an emphasis on posttranscriptional gene regulation that preserve the totipotent genome of germ cell through generations.
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About: This article is published in Cell. The article was published on 01 Dec 2006. and is currently open access. The article focuses on the topics: Germ line development & Reprogramming.
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Citations
Mitf is a transcriptional activator of medaka germ genes in culture.
Haobin Zhao,Mingyou Li,Yovita Ida Purwanti,Rong Liu,Tiansheng Chen,Zhendong Li,Ni Hong,Guijun Guan,Ao Yin,Ling Xiao,Ruowen Ge,Jianxing Song,Yunhan Hong +12 more
TL;DR: It is reported in the fish medaka that Mitf is a transcription activator of germ gene expression, a master regulator of melanocyte development, which activates melanogenic genes through binding to the E-box containing consensus CANNTG.
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Evolving Role of RING1 and YY1 Binding Protein in the Regulation of Germ-Cell-Specific Transcription.
Izabella Bajusz,Surya Henry,Surya Henry,Enikő Sutus,Enikő Sutus,Gergő Kovács,Melinda Katalin Pirity +6 more
TL;DR: A model how germ-cell-specific transcription can be governed by an RYBP centered regulatory network is proposed, underlining the possible role of RY BP in germ cell differentiation and tumorigenesis.
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Heterogeneity of primordial germ cells.
TL;DR: Variation that exists in PGCs as they navigate the many stages of this developmental journey is examined and the potential for PGC development to function as a multistage selection process that assesses heterogeneity in P GCs to refine germline quality is discussed.
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Region-specific DNA methylation in the preimplantation embryo as a target for genomic plasticity.
TL;DR: The distribution of cytosine methylation in the genome is explored and the potential effects of regional plasticity on subsequent development is discussed, enhancing understanding of how individuals are shaped not only by DNA sequence, but by the environment in which pluripotent embryonic cells are transformed into the many cell types of the body.
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A conserved node in the regulation of Vasa between an induced and an inherited program of primordial germ cell specification
TL;DR: Gustafson et al. as discussed by the authors showed that the DEAD-box RNA - helicase Vasa, a conserved germline factor, becomes enriched in the PGCs by degradation in future somatic cells by the E3-ubiquitin-ligase Gustavus.
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