Pathogenicity

TL;DR: It is proposed that immunological cues and nutrients license and tune metabolic programmes and signalling networks that communicate in a bidirectional manner to promote quiescence exit and how cell-extrinsic factors, such as nutrients and regulatory T cells, directly and indirectly balance quiescent and activation programmes in conventional T cells.

TL;DR: The evidence surveyed suggests that chronic levels of silica dust that do not cause disabling silicosis may cause the development of chronic bronchitis, emphysema, and/or small airways disease that can lead to airflow obstruction, even in the absence of radiologicalsilicosis.

TL;DR: The main mechanisms that are involved in the priming and CNS recruitment of CD4+ T cells, CD8+ T cell and regulatory T cells are highlighted and the plasticity of T cell responses in the CNS is considered, with a focus on viral infection and autoimmunity.

TL;DR: Low-dose aspirin (LDA) may be beneficial as an adjunct to standard anti-TB treatment in the later stage of active TB by reducing excess, non-productive inflammation, while enhancing Th1-cell responses for elimination of the bacilli.