Journal Article10.1023/A:1016175502756
Pathogenesis and prevention of biomaterial centered infections
157
TL;DR: The purpose of this review is to give an overview of the mechanisms involved in biomaterials centered infection and the possible methods to prevent these infections.
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Abstract: One of the major drawbacks in the use of biomedical materials is the occurrence of biomaterials centered infections. After implantation, the host interacts with a biomaterial by forming a conditioning film on its surface and an immune reaction towards the foreign material. When microorganisms can reach the biomaterials surface they can adhere to it. Adhesion of microorganisms to an implant is mediated by their physico-chemical surface properties and the properties of the biomaterials surface itself. Subsequent surface growth of the microorganisms will lead to a mature biofilm and infection, which is difficult to eradicate by antibiotics. The purpose of this review is to give an overview of the mechanisms involved in biomaterials centered infection and the possible methods to prevent these infections.
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Citations
Control of Microbial Adhesion as a Strategy for Food and Bioprocess Technology
Emiliane Andrade Araújo,Nélio José de Andrade,Luis Henrique Mendes da Silva,Antônio Fernandes de Carvalho,Cleuber Antônio de Sá Silva,Afonso Mota Ramos +5 more
TL;DR: Surface modification with the addition of the suitable compounds makes surfaces less attractive for microorganisms and therefore prevents bacterial adherence and biofilm formation.
Suppressing Bacterial Interaction with Copper Surfaces through Graphene and Hexagonal-Boron Nitride Coatings
Carolina Parra,Francisco Montero-Silva,Ricardo Henríquez,Marcos Flores,Carolina Garín,Cristian Ramírez,Macarena Moreno,Jonathan Correa,Jonathan Correa,Michael Seeger,Patricio Häberle +10 more
TL;DR: The results seem to indicate that as-grown graphene and h-BN films could successfully protect metals, preventing their corrosion in biological and medical applications.
Tuning Bacterial Attachment and Detachment via the Thickness and Dispersity of a pH-Responsive Polymer Brush.
Vivek Yadav,Yuly A. Jaimes-Lizcano,Narendra K. Dewangan,Nayoung Park,Tzu-Han Li,Megan L. Robertson,Jacinta C. Conrad +6 more
TL;DR: The results suggest that manipulating the molecular weight distribution provides a route to separately tune the attachment and detachment of bacteria.
Real Time Noninvasive Monitoring of Contaminating Bacteria in a Soft Tissue Implant Infection Model
Anton F. Engelsman,Henny C. van der Mei,Kevin P. Francis,Henk J. Busscher,Rutger J. Ploeg,Gooitzen M. van Dam +5 more
TL;DR: In vivo imaging using bioluminescent bacteria is ideally suited to study antimicrobial coatings taking into account the host immune system, and longitudinal monitoring of infection in one animal will significantly reduce the number of experiments and animals.
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