PARP-2, A Novel Mammalian DNA Damage-dependent Poly(ADP-ribose) Polymerase

TL;DR: It was found that CtIP associates in vivo with DNA damage sensor proteins such as the MRN complex (Mre11, Rad50 and NBS1) and RPA70, signal transducer proteinssuch as the PIKK kinases ATM, ATR and SMG1 and the mediator proteins 53BP1 and MDC1.

TL;DR: Fuzuloparib combined with SHR-1316 failed to improve the outcomes in unselected patients with relapsed SCLC and a recommended phase II dose (RP2D) was introduced in the stage 2 expansion phase.

TL;DR: High-throughput virtual screening of a Maybridge small molecule library using the PARP1-benzimidazole-4-carboxamide co-crystal structure and pharmacophore model led to the identification of eleven compounds, including (Z)-2-(4-hydroxybenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-8- carboxamide

TL;DR: A new criterion for triggering the extension of word hits, combined with a new heuristic for generating gapped alignments, yields a gapped BLAST program that runs at approximately three times the speed of the original.

TL;DR: A technique for conveniently radiolabeling DNA restriction endonuclease fragments to high specific activity is described, and these "oligolabeled" DNA fragments serve as efficient probes in filter hybridization experiments.

TL;DR: In this article, a technique for conveniently radiolabeling DNA restriction endonuclease fragments to high specific activity is described, where DNA fragments are purified from agarose gels directly by ethanol precipitation and are then denatured and labeled with the large fragment of DNA polymerase I, using random oligonucleotides as primers.

TL;DR: 5'-Noncoding sequences have been compiled from 699 vertebrate mRNAs and GCCA/GCCATGG emerges as the consensus sequence for initiation of translation in vertebrates.