PARP-2, A Novel Mammalian DNA Damage-dependent Poly(ADP-ribose) Polymerase
Jean-Christophe Amé,V. Rolli,Valérie Schreiber,Claude Niedergang,Françoise Apiou,Patrice Decker,Sylviane Muller,Thomas Höger,Josiane Ménissier-de Murcia,Gilbert de Murcia +9 more
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TL;DR: A cDNA encoding a 62-kDa protein that shares considerable homology with the catalytic domain of PARP-1 and also contains a basic DNA-binding domain is described, which is proposed to call this enzyme poly(ADP-ribose) polymerase 2 (PARP-2).
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About: This article is published in Journal of Biological Chemistry. The article was published on 18 Jun 1999. and is currently open access. The article focuses on the topics: Poly [ADP-Ribose] Polymerase 2 & Poly ADP ribose polymerase.
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Citations
Sex-Specific Activation of Cell Death Signalling Pathways in Cerebellar Granule Neurons Exposed to Oxygen Glucose Deprivation Followed by Reoxygenation
Jaswinder Sharma,Jaswinder Sharma,Geetha Nelluru,Mary Ann Wilson,Mary Ann Wilson,Michael V. Johnston,Michael V. Johnston,Mir Ahamed Hossain,Mir Ahamed Hossain +8 more
TL;DR: Cell death mechanisms during OGD followed by Reox in segregated male (XY) and female (XX) mouse primary CGNs are examined, finding blockade of PARP-1-AIF pathway shifts neuronal death towards a caspase-dependent mechanism.
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Insight into DNA substrate specificity of PARP1-catalysed DNA poly(ADP-ribosyl)ation.
TL;DR: PARP1-mediated DNA PARylation of DNA duplexes containing various types of breaks at different positions was characterised and a model of DNA modification by PARP1 was proposed, suggesting the biological effects of PARP-mediated ADP-ribosylation may strongly depend on the configuration of complex DNA strand breaks.
The contribution of PARP1, PARP2 and poly(ADP-ribosyl)ation to base excision repair in the nucleosomal context
M. M. Kutuzov,E A Belousova,T. A. Kurgina,A.A. Ukraintsev,Inna A. Vasil'eva,Svetlana N. Khodyreva,Olga I. Lavrik +6 more
TL;DR: In this paper, the effects of PARP1, PARP2 and PARylation on the activities of the main BER enzymes (APE1, DNA polymerase β [Polβ] and DNA ligase IIIα [LigIIIα]) in combination with BER scaffold protein XRCC1 in the nucleosomal context.
Poly(ADP-ribose) Polymerase 1 Modulates the Lethality of CHK1 Inhibitors in Mammary Tumors
TL;DR: The data demonstrate that the combination of PARP1 and CHK1 inhibitors has antitumor activity in vivo against multiple mammary tumor types and that translation of this approach could prove to be a useful anticancer therapeutic approach.
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REGULATION OF CHROMATIN STRUCTURE AND CHROMATIN-DEPENDENT TRANSCRIPTION BY POLY(ADP-RIBOSE) POLYMERASE-1 Possible targets for drug-based therapies
TL;DR: In this paper, the molecular and cellular aspects of PARP-1's chromatin-modulating activities, as well as the impact that these chromatin modulating activities have on the regulation of gene expression have been discussed.
36
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