PARP-2, A Novel Mammalian DNA Damage-dependent Poly(ADP-ribose) Polymerase
Jean-Christophe Amé,V. Rolli,Valérie Schreiber,Claude Niedergang,Françoise Apiou,Patrice Decker,Sylviane Muller,Thomas Höger,Josiane Ménissier-de Murcia,Gilbert de Murcia +9 more
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TL;DR: A cDNA encoding a 62-kDa protein that shares considerable homology with the catalytic domain of PARP-1 and also contains a basic DNA-binding domain is described, which is proposed to call this enzyme poly(ADP-ribose) polymerase 2 (PARP-2).
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About: This article is published in Journal of Biological Chemistry. The article was published on 18 Jun 1999. and is currently open access. The article focuses on the topics: Poly [ADP-Ribose] Polymerase 2 & Poly ADP ribose polymerase.
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Citations
An enzyme-linked immunosorbent poly(ADP-ribose) polymerase biomarker assay for clinical trials of PARP inhibitors
Xuesong Liu,Joann P. Palma,Robert J. Kinders,Yan Shi,Cherrie K. Donawho,Paul A. Ellis,Luis E. Rodriguez,Milagros Colon-Lopez,Mary Saltarelli,David J. LeBlond,C Thomas Lin,David Frost,Yan Luo,Vincent L. Giranda +13 more
TL;DR: The ELISA assay described here is suitable for biomarker studies in clinical trials of PARP inhibitors and able to detect 50% PAR reduction in human tumors with 80% power in a single-plate assay while assuring no more than a 10% false-positive rate.
43
Emerging small-molecule therapeutic approaches for amyotrophic lateral sclerosis and frontotemporal dementia
TL;DR: A survey of emerging small-molecule approaches for ALS and FTD therapies is provided, including targeting aberrant liquid-liquid phase separation and stress granule assembly, modulation of RNA-protein interactions, inhibition of TDP-43 phosphorylation, and inhibition of poly(ADP-ribose) polymerases (PARP).
43
New inhibitors of poly(ADP-ribose) polymerase (PARP)
Stefan Peukert,Uwe Schwahn +1 more
TL;DR: This review summarises the structural classes of known PARP-1 inhibitors, with a focus on new inhibitors published for this target, between 2002 and July 2004 and discusses the chemistry and biological data disclosed in these patent applications.
42
Poly(ADP-Ribose) Polymerases in Plants and Their Human Counterparts: Parallels and Peculiarities.
Dagmar Rissel,Edgar Peiter +1 more
TL;DR: This review critically summarizes the current understanding of poly(ADP-ribosylation) and PARP proteins in plants, highlighting similarities and differences to human PARPs, areas of controversy, and requirements for future studies.
42
Evidence to date: talazoparib in the treatment of breast cancer.
TL;DR: In this review, the development of talazoparib as well as its safety profile and the potential role of the combination therapy with standard cytotoxic drugs and with novel therapies are analyzed.
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