Journal Article10.1038/NRM2084
Palmitoylation: policing protein stability and traffic
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TL;DR: Recent studies that have provided insights into the mechanisms that mediate the functional consequences of palmitate are reviewed.
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Abstract: Palmitate modifies both peripheral and integral membrane proteins and its addition can be permanent or transient, which makes it unique among the lipid modifications of proteins. The presence of palmitate on a protein affects how the protein interacts with lipids and proteins in a membrane compartment, and the reversibility of palmitoylation allows different modes of trafficking between membrane compartments. Here, we review recent studies that have provided insights into the mechanisms that mediate the functional consequences of this versatile modification.
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Citations
Brain microstructural changes in mice persist in adulthood and are modulated by the palmitoyl acyltransferase ZDHHC7
Nicole Kerkenberg,Lydia Wachsmuth,Mingyue Zhang,Christiane Schettler,Evgeni Ponimaskin,Cornelius Faber,Bernhard T. Baune,Weiqi Zhang,Christa Hohoff +8 more
TL;DR: In this paper, the authors investigated whether developmental changes take place in hippocampus and mPFC microstructure even after 8 weeks of age and whether deficiency of ZDHHC7 impacts such age-dependent alterations.
ZDHHC15 promotes glioma malignancy and acts as a novel prognostic biomarker for patients with glioma
TL;DR: Zhang et al. as discussed by the authors showed that ZDHHC-type palmitoyltransferases (ZDHHCs) play vital roles in regulating the progression of glioma.
De Novo-Designed α-Helical Barrels as Receptors for Small Molecules
Franziska Thomas,William M. Dawson,Eric J. M. Lang,Antony J. Burton,Antony J. Burton,Gail J. Bartlett,Guto G. Rhys,Adrian J. Mulholland,Derek N. Woolfson +8 more
TL;DR: De novo-designed α-helical barrels that bind and discriminate between lipophilic biologically active molecules are described that bind the environmentally sensitive dye 1,6-diphenylhexatriene in the micromolar range and fluoresce.
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