Journal Article10.1038/NRM2084
Palmitoylation: policing protein stability and traffic
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TL;DR: Recent studies that have provided insights into the mechanisms that mediate the functional consequences of palmitate are reviewed.
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Abstract: Palmitate modifies both peripheral and integral membrane proteins and its addition can be permanent or transient, which makes it unique among the lipid modifications of proteins. The presence of palmitate on a protein affects how the protein interacts with lipids and proteins in a membrane compartment, and the reversibility of palmitoylation allows different modes of trafficking between membrane compartments. Here, we review recent studies that have provided insights into the mechanisms that mediate the functional consequences of this versatile modification.
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References
The Ubiquitin System
Avram Hershko,Aaron Ciechanover +1 more
TL;DR: This review discusses recent information on functions and mechanisms of the ubiquitin system and focuses on what the authors know, and would like to know, about the mode of action of ubi...
Basic Medical Research Award. The ubiquitin system.
TL;DR: The ubiquitin system plays important roles in the control of numerous processes, including cell-cycle progression, signal transduction, transcriptional regulation, receptor down-regulation, and endocytosis as mentioned in this paper.
3.8K
Protein prenylation: molecular mechanisms and functional consequences.
Fang L. Zhang,Patrick J. Casey +1 more
TL;DR: The emphasis in this review is on the enzymology of prenyl protein processing and the functional significance ofPrenylation in cellular events.
2.1K
Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins.
TL;DR: The role of myristate and palmitate in promoting membrane binding as well as specific membrane targeting will be reviewed, with emphasis on the Src family of tyrosine protein kinases and alpha subunits of heterotrimeric G proteins.
1.3K
An Acylation Cycle Regulates Localization and Activity of Palmitoylated Ras Isoforms
Oliver Rocks,Anna Peyker,Martin Kahms,Peter J. Verveer,Carolin Koerner,Maria Lumbierres,Jürgen Kuhlmann,Herbert Waldmann,Alfred Wittinghofer,Philippe I. H. Bastiaens +9 more
TL;DR: It is shown that the specific subcellular distribution of H- and Nras guanosine triphosphate–binding proteins is generated by a constitutive de/reacylation cycle that operates on palmitoylated proteins, driving their rapid exchange between the plasma membrane (PM) and the Golgi apparatus.
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