Journal Article10.1038/NRM2084
Palmitoylation: policing protein stability and traffic
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TL;DR: Recent studies that have provided insights into the mechanisms that mediate the functional consequences of palmitate are reviewed.
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Abstract: Palmitate modifies both peripheral and integral membrane proteins and its addition can be permanent or transient, which makes it unique among the lipid modifications of proteins. The presence of palmitate on a protein affects how the protein interacts with lipids and proteins in a membrane compartment, and the reversibility of palmitoylation allows different modes of trafficking between membrane compartments. Here, we review recent studies that have provided insights into the mechanisms that mediate the functional consequences of this versatile modification.
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Citations
Editorial: Role of protein palmitoylation in synaptic plasticity and neuronal differentiation, volume II
Kevin P. Koster,William N. Green +1 more
Technologies and Challenges in Proteomic Analysis of Protein S-acylation.
TL;DR: Current S-acylproteomics approaches are summarized, newly developed technologies promise to shed new light on this distinct post-translational modification and facilitate the discovery of new disease mechanisms, biomarkers, and therapeutic targets are reviewed.
S-acylation of the insulin-responsive aminopeptidase (IRAP): quantitative analysis and identification of modified cysteines
TL;DR: Although S-acylation regulates the intracellular trafficking of several transmembrane proteins, the effects of mutating the modified cysteines on the plasma membrane localisation of IRAP in HEK293T cells were not detected, suggesting that S-ACYlation is not essential for the movement of IR AP through the secretory pathway.
Blocking palmitoylation of Toxoplasma gondii myosin light chain 1 disrupts glideosome composition but has little impact on parasite motility
TL;DR: It is shown that mutations that uncouple the motor from what is thought to be a key structural component of the motility machinery have little impact on parasite motility, which runs counter to predictions of the current, widely-held “linear motor” model of motility.
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