Journal Article10.1002/CHIN.201140115
Palladium-Catalyzed Oxidative Trifluoromethylation of Indoles at Room Temperature.
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TL;DR: In this paper, a palladium-catalyzed oxidation strategy is applied to a wide range of substituted indoles including different substituents on the nitrogen, and it is shown that the strategy is applicable to a variety of indoles.
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Abstract: This novel palladium-catalyzed oxidation strategy is applicable to a wide range of substituted indoles including different substituents on the nitrogen.
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Citations
Transition metal-catalyzed C–H bond functionalizations by the use of diverse directing groups
TL;DR: In this article, a review of the development of utilizing functionalities as directing groups for the construction of C-C and C-hetero bonds via C-H activation using various transition metal catalysts is presented.
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Palladium(II)-Catalyzed Oxidative Difunctionalization of Alkenes: Bond Forming at a High-Valent Palladium Center.
Guoyin Yin,Xin Mu,Guosheng Liu +2 more
TL;DR: In this article, a steric bulky ligand was used to promote the reductive elimination steps from the Pd(II) center and impeding the β-hydride elimination reactions, which are beyond the scope of this Account.
625
Recent advances in the trifluoromethylation methodology and new CF3-containing drugs
Wei Zhu,Jiang Wang,Shuni Wang,Zhanni Gu,José Luis Aceña,Kunisuke Izawa,Hong Liu,Vadim A. Soloshonok,Vadim A. Soloshonok +8 more
TL;DR: A brief assessment of the methodological field of trifluoromethylation and its possible impact on the development of new CF 3 -containing pharmaceuticals is provided in this paper.
427
References
Fluorine in Pharmaceuticals: Looking Beyond Intuition.
TL;DR: Experimental progress in exploration of the specific influence of carbon-fluorine single bonds on docking interactions is reviewed and complementary analysis based on comprehensive searches in the Cambridge Structural Database and the Protein Data Bank is added.
5.8K
Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions
TL;DR: This is the first comprehensive review encompassing the large body of work in this field over the past 5 years, and will focus specifically on ligand-directed C–H functionalization reactions catalyzed by palladium.
Palladium(II)-catalyzed C-H activation/C-C cross-coupling reactions: versatility and practicality.
TL;DR: A review of palladium-catalyzed coupling of CH bonds with organometallic reagents through a PdII/Pd0 catalytic cycle can be found in this paper.