Journal Article10.7326/0003-4819-140-8-200404200-00010
Pain: Moving from Symptom Control toward Mechanism-Specific Pharmacologic Management
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TL;DR: The neurobiological mechanisms responsible for these different pains are beginning to be defined, providing insight into how distinct types of pain are generated by diverse etiologic factors, and in which patients can now realistically expect to move from an empirical therapeutic approach to one that is targeted specifically at the particular mechanisms of the type of pain experienced by an individual patient.
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Abstract: Several distinct types of pain exist: nociceptive, inflammatory, neuropathic, and functional. By defining the mechanisms responsible for each type of pain, neurophysiologic research is providing in...
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Citations
An update of the appraisal of the accuracy and utility of cervical discography in chronic neck pain.
Obi Onyewu,Laxmaiah Manchikanti,Frank J E Falco,Singh,Stephanie Geffert,Helm S nd,Steven P. Cohen,Joshua A Hirsch +7 more
TL;DR: Cervical provocation discography may be an important evaluation tool in certain contexts to identify a subset of patients with chronic neck pain secondary to intervertebral disc disorders, according to the current systematic review.
Investigating the interplay of chronic pain intensity and psychosocial factors in adult women: A pilot study from Türkiye
Buğra Yıldırım,Ayşe Mine İşler,Meltem Oral,Halil Peksen,Sefa Cıceklıyurt,Cengiz Kılıç,Derya Çakmak Karapınar,Feyza Nur Aydogan +7 more
TL;DR: This cross-sectional study of 405 adult women in Türkiye explores the relationships between chronic pain intensity, quality of life, pain coping strategies, and pain beliefs, revealing weak correlations and a 21.2% explained variance in chronic pain intensity.
Pain and its control
Henry McQuay
TL;DR: Chronic pain's subjective nature is linked to depression, with pain perception altered by mood and vice versa; effective pain control requires a combination of conventional and unconventional analgesics, not substitution of weaker agents.
Tocotrienol Affects Oxidative Stress, Cholesterol Homeostasis and the Amyloidogenic Pathway in Neuroblastoma Cells: Consequences for Alzheimer's Disease.
Marcus O. W. Grimm,Liesa Regner,Janine Mett,Christoph P Stahlmann,Pascal Schorr,Christopher Nelke,Olga Streidenberger,Hannah Stoetzel,Jakob Winkler,Shatha R. Zaidan,Andrea Thiel,Kristina Endres,Heike S. Grimm,Dietrich A. Volmer,Tobias Hartmann,Tobias Hartmann +15 more
TL;DR: The results might help to understand the controversial findings of vitamin E studies and demonstrate that besides the known positive neuroprotective properties, tocotrienols also have negative characteristics with respect to AD.
AAAPT Diagnostic Criteria for Acute Low Back Pain with and Without Lower Extremity Pain.
Andrea L. Nicol,Meredith C.B. Adams,Debra B. Gordon,Sohail K. Mirza,David Dickerson,Sean Mackey,David A. Edwards,Robert W. Hurley +7 more
TL;DR: A multidimensional conceptual taxonomy is proposed to enable more rigorous meta-analyses and promote more generalizable studies of interindividual variation in acute low back pain and its potential underlying mechanisms.
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