Journal Article10.7326/0003-4819-140-8-200404200-00010
Pain: Moving from Symptom Control toward Mechanism-Specific Pharmacologic Management
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TL;DR: The neurobiological mechanisms responsible for these different pains are beginning to be defined, providing insight into how distinct types of pain are generated by diverse etiologic factors, and in which patients can now realistically expect to move from an empirical therapeutic approach to one that is targeted specifically at the particular mechanisms of the type of pain experienced by an individual patient.
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Abstract: Several distinct types of pain exist: nociceptive, inflammatory, neuropathic, and functional. By defining the mechanisms responsible for each type of pain, neurophysiologic research is providing in...
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Cyclooxygenases 1 and 2
TL;DR: The discovery ofCOX-2 has made possible the design of drugs that reduce inflammation without removing the protective PGs in the stomach and kidney made by COX-1, which may not only be anti-inflammatory but may also be active in colon cancer and Alzheimer's disease.
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Molecular mechanisms of nociception
David Julius,Allan I. Basbaum +1 more
TL;DR: Efforts to determine how primary sensory neurons detect pain-producing stimuli of a thermal, mechanical or chemical nature have revealed new signalling mechanisms and brought us closer to understanding the molecular events that facilitate transitions from acute to persistent pain.
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Pain affect encoded in human anterior cingulate but not somatosensory cortex.
TL;DR: These findings provide direct experimental evidence in humans linking frontal-lobe limbic activity with pain affect, as originally suggested by early clinical lesion studies.
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From Ionic Currents to Molecular Mechanisms: The Structure and Function of Voltage-Gated Sodium Channels
TL;DR: Together, these studies showed that the mechanisms of sodium channel function and regulation, purified sodium channel protein contained the essential and gives a perspective for future research on the ex-elements for ion conduction and voltage-dependent panding family of Sodium channel proteins.
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