Journal Article10.1016/J.JAD.2020.05.078
Paeoniflorin ameliorates depressive-like behavior in prenatally stressed offspring by restoring the HPA axis- and glucocorticoid receptor- associated dysfunction.
Ying chun Li,Xing Xing Zheng,Si zhe Xia,Yang Li,Huan huan Deng,Xing Wang,Yi wei Chen,Yi song Yue,Jiao He,Yan jun Cao,Yan jun Cao +10 more
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TL;DR: It is shown that PA has antidepression-like effects in male PS offspring, partially due to the HPA axis, GR dysfunction and Glu transport system.
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About: This article is published in Journal of Affective Disorders. The article was published on 01 Sep 2020. The article focuses on the topics: Offspring & Neurogranin.
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Citations
Study of Antidepressant-Like Effects of Albiflorin and Paeoniflorin Through Metabolomics From the Perspective of Cancer-Related Depression
TL;DR: The data indicate that AF and PF could effectively ameliorate a depression-like state in the model rats, and the mechanism may be associated with the regulation of the neuroendocrine immune system and disrupted metabolic pathways.
Essential oil from the roots of Paeonia lactiflora pall. has protective effect against corticosterone-induced depression in mice via modulation of PI3K/Akt signaling pathway
TL;DR: This study found that EOP had a significant antidepressant effect on the symptoms of CORT-induced depression in mice, and significantly down-regulated the levels of CRH, ACTH and cortisol in the brain tissues of mice.
Efficacy of paeoniflorin on models of depression: A systematic review and meta-analysis of rodent studies.
Xiaoliang Wang,Ya-Ting Wang,Zhen Guo,Ning-ning Zhang,Yuan Wang,Die Hu,Zhen-zhen Wang,Yi Zhang +7 more
TL;DR: In this paper , a systematic review and meta-analysis aimed to assess the effectiveness of paeoniflorin in relieving depressive-like behaviors in animal models, including forced swimming, tail suspension, and open field tests.
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Paeoniflorin ameliorates oxidase stress in Glutamate-stimulated SY5Y and prenatally stressed female offspring through Nrf2/HO-1 signaling pathway.
Xing Wang,Jin cheng Hao,Bo Shang,Kai lin Yang,Xiao zhou He,Zhao liang Wang,Hui ling Jing,Yan jun Cao,Yan jun Cao +8 more
TL;DR: Zhang et al. as discussed by the authors used a prenatal restraint stress model and Glu-induced excitotoxic neurotoxicity in SH-SY5Y cells to study the effects of Paeoniflorin (PF), which can ameliorate learning and memory impairments and increase the density of hippocampal neurons, typical Golgi-positive pyramidal cells, and neuronal Neurogranin (Ng) expression in PS rat offspring.
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Fluoxetine increases astrocytic glucose uptake and glycolysis in corticosterone-induced depression through restricting GR-TXNIP-GLUT1 Pathway
TL;DR: Results demonstrated that fluoxetine increased astrocytic glucose uptake and glycolysis in corticosterone-induced depression via restricting GR-TXNIP-GLUT1 pathway.
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