Journal Article10.1002/smll.202200116
Oxygen Self-Supply Engineering-Ferritin for the Relief of Hypoxia in Tumors and the Enhancement of Photodynamic Therapy Efficacy.
Yang Zhu,Duo Jin,Manman Liu,Yi Dai,Li Li,Xinwei Zheng,Lulu Wang,Aizong Shen,Jianing Yu,Sisi Wu,Yun Wu,Kai Zhong,Junjie Cheng,Yangzhong Liu +13 more
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TL;DR: This bio-mimic Ftn strategy not only improves the in vivo distribution and retention of Ce6, but also enhances the effectiveness and precision of PDT by TME modulation.
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Abstract: Hypoxia is a hallmark of the tumor microenvironment (TME) that promotes tumor development and metastasis. Photodynamic therapy (PDT) is a promising strategy in the treatment of tumors, but it is limited by the lack of oxygen in TME. In this work, an O2 self-supply PDT system is constructed by co-encapsulation of chlorin e6 (Ce6) and a MnO2 core in an engineered ferritin (Ftn), generating a nanozyme promoted PDT nanoformula (Ce6/Ftn@MnO2 ) for tumor therapy. Ce6/Ftn@MnO2 exhibits a uniform small size (15.5 nm) and high stability due to the inherent structure of Ftn. The fluorescence imaging and immunofluorescence analysis demonstrate the pronounced accumulation of Ce6/Ftn@MnO2 in the tumors of mice, and the treatment significantly decreases the expression of hypoxia-inducible factor (HIF)-1α. The Ce6/Ftn@MnO2 nanoplatform exerts a more potent anti-tumor efficacy with negligible damage to normal tissues compared to the treatment with free Ce6. Moreover, the weak acidity and the presence of H2 O2 in TME significantly enhances the r1 relativity of Ce6/Ftn@MnO2 , resulting in a prominent enhancement of MRI imaging in the tumor. This bio-mimic Ftn strategy not only improves the in vivo distribution and retention of Ce6, but also enhances the effectiveness and precision of PDT by TME modulation.
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Citations
Bioactive inorganic nanomaterials for cancer theranostics.
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TL;DR: In this paper , the authors summarized the recent progress of bioactive inorganic nanomaterials in cancer theranostics, and also introduced the definition, synthesis and modification strategies of Bioactive Inorganic NOMs.
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Nanozymes for Regenerative Medicine
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Amplification of Lipid Peroxidation by Regulating Cell Membrane Unsaturation to Enhance Chemodynamic Therapy.
Yang Zhu,Peng Gong,Jun Wang,Junjie Cheng,Wenyu Wang,Huilan Cai,Rujiang Ao,Hongwei Huang,Meili Yu,Lisen Lin,Xiaoyuan Chen +10 more
TL;DR: In this paper , a self-reinforcing CDT agent called Oleanolic acid (OA)-loaded iron single-atom catalyst (Fe-SAC)-embedded hollow carbon nanosphere encapsulated by erythrocyte membrane (EM) was proposed.
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Enhancing Catalytic Activity of a Nickel Single Atom Enzyme by Polynary Heteroatom Doping for Ferroptosis-Based Tumor Therapy.
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TL;DR: In this paper , an anion exchange strategy for precisely controlled production of an edge-rich sulfur and nitrogendecorated nickel single atom enzyme (S-N/Ni PSAE) was developed.
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Gas-Mediated Tumor Energy Remodeling for Sensitizing Mild Photothermal Therapy.
Junjie Cheng,Yang Zhu,Yi Dai,Li Li,Miya Zhang,Duo Jin,Manman Liu,Jiaji Yu,Wenxin Yu,Jianhua Zou,Xiaoyuan Chen,Yangzhong Liu +11 more
TL;DR: In this article , a gas-mediated energy remodeling strategy was proposed to enhance the efficacy of mild photothermal therapy at moderate temperatures while minimizing side effects, which proved to be highly effective in disrupting the mitochondrial respiratory chain, inhibiting ATP generation, and reducing the overexpression of heat shock protein 90.
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