Oxygen-Evolving Mesoporous Organosilica Coated Prussian Blue Nanoplatform for Highly Efficient Photodynamic Therapy of Tumors.
Zhen Lu Yang,Wei Tian,Qing Wang,Ying Zhao,Yun Lei Zhang,Ying Tian,Yu Xia Tang,Shouju Wang,Ying Liu,Qianqian Ni,Guangming Lu,Zhaogang Teng,Long Jiang Zhang +12 more
TL;DR: It is confirmed that the PB@PMO‐Ce6 nanoplatform can generate more ROS to enhance PDT than free Ce6 in cellular level, and in vivo, the singlet oxygen sensor green staining, tumor volume of tumor‐bearing mice, and histopathological analysis demonstrate that this oxygen‐evolving nanoplplatform can elevate singlets oxygen to effectively inhibit tumor growth without obvious damage to major organs.
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Abstract: Oxygen (O2) plays a critical role during photodynamic therapy (PDT), however, hypoxia is quite common in most solid tumors, which limits the PDT efficacy and promotes the tumor aggression. Here, a safe and multifunctional oxygen-evolving nanoplatform is costructured to overcome this problem. It is composed of a prussian blue (PB) core and chlorin e6 (Ce6) anchored periodic mesoporous organosilica (PMO) shell (denoted as PB@PMO-Ce6). In the highly integrated nanoplatform, the PB with catalase-like activity can catalyze hydrogen peroxide to generate O2, and the Ce6 transform the O2 to generate more reactive oxygen species (ROS) upon laser irradiation for PDT. This PB@PMO-Ce6 nanoplatform presents well-defined core-shell structure, uniform diameter (105 ± 12 nm), and high biocompatibility. This study confirms that the PB@PMO-Ce6 nanoplatform can generate more ROS to enhance PDT than free Ce6 in cellular level (p < 0.001). In vivo, the singlet oxygen sensor green staining, tumor volume of tumor-bearing mice, and histopathological analysis demonstrate that this oxygen-evolving nanoplatform can elevate singlet oxygen to effectively inhibit tumor growth without obvious damage to major organs. The preliminary results from this study indicate the potential of biocompatible PB@PMO-Ce6 nanoplatform to elevate O2 and ROS for improving PDT efficacy.
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Citations
Recent Advancements in Nanomedicine for 'Cold' Tumor Immunotherapy.
Qinjun Chen,Tao Sun,Chen Jiang +2 more
TL;DR: In this article, the authors summarized the mechanisms underlying immunosuppressive TIM in cold tumors and addressed the recent advancements in nanotechnology for cold TIM reversal-based therapies, as well as a brief talk about the feasibility of clinical translation.
Application of nanotechnology for enhancing photodynamic therapy via ameliorating, neglecting, or exploiting tumor hypoxia
Danrong Hu,Meng Pan,Yan Yu,Ao Sun,Kun Shi,Ying Qu,Zhiyong Qian +6 more
- 01 Mar 2020
TL;DR: An overview of the recent trend in the modulation and utilization of tumor hypoxia via nanomedicine‐based strategies, followed by a summary of the design and mechanisms of these nanosystems to improve PDT is presented.
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Periodic mesoporous organosilicas (PMOs): From synthesis strategies to applications
01 Apr 2022
TL;DR: A comprehensive review of periodic mesoporous organosilicas can be found in this article , which highlights the recent advances that have been achieved concerning their synthesis, morphology, functionalities, and applications mainly after 2014.
62
Near Infrared-Triggered Theranostic Nanoplatform with Controlled Release of HSP90 Inhibitor for Synergistic Mild Photothermal and Enhanced Nanocatalytic Therapy with Hypoxia Relief.
Boshi Tian,Chen Wang,Yaqian Du,Shuming Dong,Lili Feng,Bin Liu,Shikai Liu,He Ding,Shili Gai,Fei He,Piao Ping Yang +10 more
TL;DR: A near-infrared (NIR)-triggered theranostic nanoplatform (GA-PB@MONs@LA) is designed for synergistic mild PTT and enhanced Fenton nanocatalytic therapy against hypoxic tumors.
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The theranostic nanoagent Mo2C for multi-modal imaging-guided cancer synergistic phototherapy.
Qun Zhang,Weicheng Huang,Chunyu Yang,Fei Wang,Fei Wang,Chuanqi Song,Yan Gao,Yunfeng Qiu,Mei Yan,Bin Yang,Chongshen Guo +10 more
TL;DR: Mo2C proposed herein has been proven to be applicable as a photoacoustic imaging and CT imaging contrast agent for in vivo tumor depiction; furthermore, Mo2C demonstrates excellent biocompatibility, showing minimal hematotoxicity and tissue toxicity.
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Continuous O2-Evolving MnFe2O4 Nanoparticle-Anchored Mesoporous Silica Nanoparticles for Efficient Photodynamic Therapy in Hypoxic Cancer
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