Journal Article10.1021/CR960421S
Oxidative Nucleobase Modifications Leading to Strand Scission
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About: This article is published in Chemical Reviews. The article was published on 01 Apr 1998.
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Citations
Recognition and reaction of metallointercalators with DNA.
TL;DR: A more complete understanding of how to target DNA sites with specificity will lead not only to novel chemotherapeutics but also to a greatly expanded ability for chemists to probe DNA and to develop highly sensitive diagnostic agents.
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TL;DR: The properties of other guanine oxidation products and the associated DNA glycosylases that remove them are now also being revealed.
Long-range charge transfer in DNA: transient structural distortions control the distance dependence.
TL;DR: A mechanism for long-range charge transport in DNA that depends on its spontaneous structural distortion, which is called phonon-assisted polaron hopping is described, which provides a framework for understanding the reactions and charge-transport properties of DNA.
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References
Topology and reorganization of a human TFIID–promoter complex
TL;DR: The data provide insight into the relative disposition of DNA and several TFIID subunits, as well as evidence for DNA wrapping by TFIIDs, and suggest a direct role of TFIIA in the stable positioning of promoter DNA relative to TAFs.
259
Distribution of UV light-induced damage in a defined sequence of human DNA: detection of alkaline-sensitive lesions at pyrimidine nucleoside-cytidine sequences
TL;DR: The results show that the distribution of UV light-induced cyclobutane dimers within a defined sequence is similar whether the DNA is exposed to UV light as part of the chromosome of intact cells or as naked DNA, however, the cellular environment shields the nuclear DNA, resulting in about 50% decrease in apparent dose.
258
Nitric oxide induces oxidative damage in addition to deamination in macrophage DNA.
TL;DR: Results demonstrate that NO plays a dual role in damaging the DNA of activated macrophages and is also an obligatory factor in oxidative damage to DNA.
248
Stabilization of Z DNA in vivo by localized supercoiling
AR Rahmouni,Robert D. Wells +1 more
TL;DR: The existence of the Z structure for commonly found natural sequences is demonstrated and supported and the notion of domains of negative supercoiling in vivo is supported.
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