Journal Article10.1021/CR960421S
Oxidative Nucleobase Modifications Leading to Strand Scission
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About: This article is published in Chemical Reviews. The article was published on 01 Apr 1998.
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Citations
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TL;DR: A mechanism for long-range charge transport in DNA that depends on its spontaneous structural distortion, which is called phonon-assisted polaron hopping is described, which provides a framework for understanding the reactions and charge-transport properties of DNA.
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References
Formation of 7,8-dihydro-8-oxoguanine in the 1,2-dioxetane-induced oxidation of calf thymus dna : evidence for photosensitized dna damage by thermally generated triplet ketones in the dark
TL;DR: 1,2‐dioxetanes are efficient DNA oxidants and excellent tools to study photooxidation reactions of DNA in the dark as well as a chemical source of singlet oxygen.
41
Synthesis, dna binding, and cleaving properties of an ellipticine : salen.copper conjugate
Sylvain Routier,Jean-Luc Bernier,Jean-Pierre Catteau,Pierre Colson,Claude Houssier,Christian Rivalle,Emile Bisagni,Christian Bailly +7 more
TL;DR: Spectroscopic measurements indicate that the intercalation geometry of the ellipticine chromophore is preserved with the hybrid, and the cleavage is much more efficient with the conjugate than with the Schiff base copper complex alone.
39
Sequence‐specificity of the alkali‐sensitive lesions induced in dna by high‐intensity ultraviolet laser radiation
TL;DR: It has been shown with fragments of plasmids pUC18, pUC19 and pBR322 that the relative efficiency of ASLs at deoxyguanosine sites depends on the primary structure context and can differ by an order of magnitude.
39
Peroxy radical oxidation of thymidine.
Michela Martini,John Termini +1 more
TL;DR: A plausible mechanistic scheme for the formation of the base oxidation products of thymidine by peroxy radicals is presented and attach at the deoxyribose moiety resulting in oxidative depyrimidination is also found to occur, as indicated by free base release.
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