Book Chapter10.1007/978-3-642-74529-4_2
Overview of the mucosal immune system.
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TL;DR: The molecular basis for local immunity was established when Tomasi et al. (1965) confirmed that external secretions contained a unique immunoglobulin (Ig) subsequently called secretory IgA (SIgA).
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Abstract: The existence of a protective local immune system that seemed to function independently of systemic immunity, was initially proposed by Besredka (1919); he observed that rabbits, after oral immunization with killed Shiga bacillus, were protected against fatal dysentery irrespective of the serum antibody titer. Davies (1922) obtained evidence in soldiers stationed around Jerusalem, to suggest for the first time the presence of local immunity in humans; his observations indicated that bacterial agglutinins could appear in dysentery stools several days earlier than in the blood. The molecular basis for local immunity was established when Tomasi et al. (1965) confirmed that external secretions contained a unique immunoglobulin (Ig) subsequently called secretory IgA (SIgA).
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References
Up-regulation of the expression of secretory component and HLA molecules in a human colonic cell line by tumour necrosis factor-alpha and gamma interferon.
Dag Kvale,P Brandtzaeg,D Løvhaug +2 more
TL;DR: It is shown that both the production and surface membrane expression of SC were additively up‐regulated by tumour necrosis factor‐α (TNF) and gamma inferreron (IFN‐γ) in a human colonic cell line (HT‐29m2), suggesting that transcriptional events are required for the cytokine‐mediated up‐regulation of SC.
127
•Journal Article
Contribution of immunoglobulin-secreting cells in the murine small intestine to the total 'background' immunoglobulin production.
TL;DR: The results show that in C3H/He mice of 20 weeks of age, on average 16 x 10(6) Ig-SC can be isolated from the small intestine, and this indicates that the mucosal tissues are the major site of 'background' Ig-production.
122
•Journal Article
Many Bacterial Species Bind Human IgD
Arne Forsgren,Anders Grubb +1 more
TL;DR: Binding studies with radiolabeled IgD Fab and Fc fragments indicated that the binding mainly but not exclusively involves the CH1 region of the IgD molecule.
111
A model system for peptide hormone action in differentiation: Interleukin 2 induces a B lymphoma to transcribe the J chain gene
TL;DR: A specific function for IL-2 in B cell differentiation is defined and the IL- 2/BCL1 system provides a model for examining the mechanism by which signals generated by hormone-receptor interaction are transmitted to the nucleus and regulate gene expression.
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