Outer retinal tubulation: a novel optical coherence tomography finding
Sandrine A. Zweifel,Michael Engelbert,Ketan Laud,Ron Margolis,Richard F. Spaide,K. Bailey Freund +5 more
TL;DR: Degenerating photoreceptors may become arranged in a circular or ovoid fashion during a process proposed to term outer retinal tubulation, apparently common in advanced diseases affecting the outer retina and retinal pigment epithelium.
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Abstract: Objective To describe tubular structures found in the outer retina seen in a variety of retinal disorders. Methods Sixty-nine eyes of 63 patients were examined with spectral-domain optical coherence tomography. Optical coherence tomography C-scans were correlated with their corresponding B-scans. The prevalence, number, size, and shape of the tubular structures were determined. Results Branching tubules were identified in the outer retina of 54 patients with age-related macular degeneration and in 9 patients with other diagnoses. The tubules appeared as round or ovoid hyporeflective spaces with hyperreflective borders on the B-scans, measuring 40 to 140 Μm high and 40 to 2260 Μm wide. Morphologic features ranged from single straight or branching tubules to complex cavitary networks, usually overlying areas of pigment epithelial alteration or subretinal fibrosis. The tubules generally remained stable over time. In a retinal practice specializing in advanced age-related macular degeneration, these structures were identified in 60 of 248 patients (24.2%) seen during a 3-month period. Conclusions Degenerating photoreceptors may become arranged in a circular or ovoid fashion during a process we propose to term outer retinal tubulation. These changes are apparently common in advanced diseases affecting the outer retina and retinal pigment epithelium. This observation has practical implications because these findings can be misinterpreted as intraretinal or subretinal fluid, possibly prompting unnecessary interventions.
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Outer retinal tubulations in central serous chorioretinopathy associated with choroidal neovascularisation
Spoorti Krishna Reddy Mandadi,Claudio Iovino,Riccardo Sacconi,Giuseppe Querques,Enrico Peiretti,Sumit Randhir Singh,Jay Chhablani +6 more
TL;DR: Outdoor retinal tubulations associated with choroidal neovascularisation in chronic central serous chorioretinopathy, though less frequent, when present are more numerous, mostly extrafoveal and more spheroidal in shape compared to outer retinal Tubulation associated with age-related macular degeneration and other degenerative conditions.
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OCT Angiography and En Face OCT Reflectance Aid in Monitoring Subclinical Inflammation in Serpiginous Choroidopathy.
TL;DR: OCTA is recommended on all patients with serpiginous choroidopathy to monitor underlying state of inflammation and help determine immunosuppressive threshold, supporting the hypothesis that the choriocapillaris is the primary site of inflammation in SC.
Sub-retinal pigment epithelium tubules in non-neovascular age-related macular degeneration
Serena Fragiotta,Mariacristina Parravano,Riccardo Sacconi,Eliana Costanzo,Daniele De Geronimo,Francesco Prascina,Vittorio Capuano,Eric H Souied,Ian C. Han,Robert F. Mullins,Giuseppe Querques +10 more
TL;DR: In this article , a novel optical coherence tomography (OCT) signature resembling sub-retinal pigment epithelium (RPE) tubules (SRT) was described in non-neovascular age-related macular degeneration (AMD).
Multimodal Retinal Imaging Reveals New Pathogenic Insights in Central Areolar Choroidal Dystrophy: A Case Series.
TL;DR: In this article , a 19-year-old asymptomatic woman was referred for bilateral macular defects of the retinal pigment epithelium (RPE), and a multimodal assessment of her left eye disclosed a single parafoveal spot of decreased pigmentation that was clearly visible as hyper-autofluorescent using BAF and as hypo-autopigmented using NIR-AF.
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Prevalence and optical coherence tomography analyses of outer retinal tubulations in Chinese population with inherited retinal diseases
Yuhong Chen,Jieqiong Chen,Hong Wang,Yang Yu,Wenqiu Wang,Wenjia Liu,Suqin Yu,Yuanyuan Gong,Huixun Jia,Tong Li,Xiaodong Sun +10 more
- 08 Aug 2023
TL;DR: The prevalence of ORT varies among different IRDs phenotypes, with the highest prevalence in BCD, and the presence of choroidal atrophy and INL cysts may be associated with an increased risk of ORT formation in patients with IRD.
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