Outer retinal tubulation: a novel optical coherence tomography finding
Sandrine A. Zweifel,Michael Engelbert,Ketan Laud,Ron Margolis,Richard F. Spaide,K. Bailey Freund +5 more
TL;DR: Degenerating photoreceptors may become arranged in a circular or ovoid fashion during a process proposed to term outer retinal tubulation, apparently common in advanced diseases affecting the outer retina and retinal pigment epithelium.
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Abstract: Objective To describe tubular structures found in the outer retina seen in a variety of retinal disorders. Methods Sixty-nine eyes of 63 patients were examined with spectral-domain optical coherence tomography. Optical coherence tomography C-scans were correlated with their corresponding B-scans. The prevalence, number, size, and shape of the tubular structures were determined. Results Branching tubules were identified in the outer retina of 54 patients with age-related macular degeneration and in 9 patients with other diagnoses. The tubules appeared as round or ovoid hyporeflective spaces with hyperreflective borders on the B-scans, measuring 40 to 140 Μm high and 40 to 2260 Μm wide. Morphologic features ranged from single straight or branching tubules to complex cavitary networks, usually overlying areas of pigment epithelial alteration or subretinal fibrosis. The tubules generally remained stable over time. In a retinal practice specializing in advanced age-related macular degeneration, these structures were identified in 60 of 248 patients (24.2%) seen during a 3-month period. Conclusions Degenerating photoreceptors may become arranged in a circular or ovoid fashion during a process we propose to term outer retinal tubulation. These changes are apparently common in advanced diseases affecting the outer retina and retinal pigment epithelium. This observation has practical implications because these findings can be misinterpreted as intraretinal or subretinal fluid, possibly prompting unnecessary interventions.
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References
Photoreceptor Rosettes with Blue Cone Opsin Immunoreactivity in Retinitis Pigmentosa
Ann H. Milam,Samuel G. Jacobson +1 more
TL;DR: A method to circumvent the problem of routine storage of tissues in fixatives that reduce or destroy antigenicity is developed and light and electron microscopic histopathology and immunocytochemistry of an unusual retina from a 76-year-old man with multiplex RP are reported.
74
Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance
TL;DR: Pax6 overexpression does not obviously impair the initial formation of the eye and its major cell-types but prevents normal development of the retina from about E14.5, leading eventually to severe retinal degeneration in postnatal life.
In vivo requirement of protein prenylation for maintenance of retinal cytoarchitecture and photoreceptor structure.
TL;DR: The results implicate a defect in protein prenylation in the lovastatin- induced retinal degeneration, and suggest the presence of a dynamic pathway in the retina that requires isoprenylated proteins to maintain retinal cytoarchitecture.
Photoreceptor rosettes in autosomal dominant retinitis pigmentosa with reduced penetrance.
TL;DR: To the knowledge, this is the first report of photoreceptor rosettes containing rod photoreceptors in a case of retinitis pigmentosa, and future studies of additional patients will be needed to determine if the rod-abundant ro settes seen in this patient are a characteristic finding of autosomal dominant retinopathy pigmentosa with reduced penetrance.
44
Cone photoreceptors in laminated retinal transplants.
TL;DR: Full-thickness embryonic rabbit retinal transplants develop into laminated retinas with well-developed photoreceptor outer segment and the ratio between the two cone types is the same as in the normal adult rabbit retina.
3