Journal Article10.1016/J.CLINTHERA.2019.10.005
Outcomes of Macrolide Deescalation in Severe Community-acquired Pneumonia.
7
TL;DR: In this study of ICU patients with severe CAP and a negative BioFire PCR result, deescalation from combination β-lactam and macrolide therapy to β- lactam monotherapy was not associated with increased in-hospital mortality but was associated with decreased hospital and ICU LOS.
read more
About: This article is published in Clinical Therapeutics. The article was published on 29 Oct 2019. The article focuses on the topics: Community-acquired pneumonia & Intensive care unit.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Detection of Multidrug-Resistant Enterobacterales-From ESBLs to Carbapenemases.
TL;DR: In this paper, a review of the current methods for detection of multidrug-resistant enterobacterales (MDRE) infections is presented with a focus on culture-based and molecular techniques.
40
The Global Burden of Community-Acquired Pneumonia in Adults, Encompassing Invasive Pneumococcal Disease and the Prevalence of Its Associated Cardiovascular Events, with a Focus on Pneumolysin and Macrolide Antibiotics in Pathogenesis and Therapy
J. Anderson,Charles Feldman +1 more
TL;DR: In this paper , the authors present an update on the prevalence and types of cardiovascular events associated with acute bacterial CAP, particularly IPD, focusing on recent insights into the involvement of pneumococcal pore-forming toxin, pneumolysin (Ply), in subverting host immune defenses, particularly the protective functions of the alveolar macrophage during early stage disease.
A profile of the GenePOC Carba C assay for the detection and differentiation of gene sequences associated with carbapenem-non-susceptibility.
Luis Lucena Baeza,Axel Hamprecht +1 more
TL;DR: The performance of the GenePOC/Revogene Carba C assay is evaluated and other currently available methods for the detection of carbapenemases are reviewed.
4
The Global Burden of Community-Acquired Pneumonia, Encompassing Invasive Pneumococcal Disease and the Prevalence of Its Associated Cardiovascular Events, With a Focus on Pneumolysin and Macrolide Antibiotics in Pathogenesis and Therapy
30 May 2023
TL;DR: In this paper , the authors present an update on the prevalence and types of cardiovascular events associated with acute bacterial CAP, particularly IPD, focusing on recent insights into the involvement of pneumococcal pore-forming toxin, pneumolysin (Ply), in subverting host immune defenses, particularly the protective functions of the alveolar macrophage during early stage disease.
4
Etiology and efficacy of anti-microbial treatment for community-acquired pneumonia in adults requiring hospital admission in Ukraine
Igor Kaidashev,A. N. Lavrenko,Tatiana Baranovskaya,Victor Blazhko,Nataliia I. Digtiar,Oleksandr Dziublyk,N. D. Gerasimenko,Liudmyla Iashyna,V F Kryvetskyi,Lesya Kuryk,V. Rodionova,Roman Stets,Ivan Vyshnyvetskyy,Y. M. Feshchenko +13 more
TL;DR: Delafloxacin is a promising effective antibiotic for monotherapy of CAP in adults and could be used in cases of antimicrobial-resistant strains.
3
References
Infectious Diseases Society of America/American Thoracic Society Consensus Guidelines on the Management of Community-Acquired Pneumonia in Adults
Lionel A. Mandell,Richard G. Wunderink,Antonio Anzueto,John G. Bartlett,G. Douglas Campbell,Nathan C. Dean,Nathan C. Dean,Scott F. Dowell,Daniel M. Musher,Daniel M. Musher,Michael S. Niederman,Michael S. Niederman,Antoni Torres,Cynthia G. Whitney,Michael E. DeBakey Veterans +14 more
TL;DR: This work presents a meta-analyses of the immune system’s response to chronic obstructive pulmonary disease and shows clear patterns of decline in the immune systems of elderly patients with compromised immune systems.
Community-acquired pneumonia requiring hospitalization among U.S. adults
Seema Jain,Derek J. Williams,Sandra R. Arnold,Krow Ampofo,Anna M. Bramley,Carrie Reed,Chris Stockmann,Evan J. Anderson,Carlos G. Grijalva,Wesley H. Self,Yuwei Zhu,Anami Patel,Weston Hymas,James D. Chappell,Robert A. Kaufman,J. Herman Kan,David Dansie,Noel Lenny,David R. Hillyard,Lia M. Haynes,Min Z. Levine,Stephen Lindstrom,Jonas M. Winchell,Jacqueline M. Katz,Dean D. Erdman,Eileen Schneider,Lauri A. Hicks,Richard G. Wunderink,Kathryn M. Edwards,Andrew T. Pavia,Jonathan A. McCullers,Lyn Finelli +31 more
TL;DR: The incidence of community-acquired pneumonia requiring hospitalization was highest among the oldest adults and despite current diagnostic tests, no pathogen was detected in the majority of patients.
Adults Hospitalized With Pneumonia in the United States: Incidence, Epidemiology, and Mortality.
Julio A. Ramirez,Timothy L. Wiemken,Paula Peyrani,Forest W Arnold,Robert Kelley,William A. Mattingly,Raul Nakamatsu,Senen Pena,Brian E. Guinn,Stephen Furmanek,Annuradha Persaud,Anupama Raghuram,Francisco Fernández,Leslie A Beavin,Rahel Bosson,Rafael Fernandez-Botran,Rodrigo Cavallazzi,Jose Bordon,Claudia Valdivieso,Joann Schulte,Ruth Carrico +20 more
TL;DR: The estimated US burden of CAP is substantial, with >1.5 million unique adults being hospitalized annually, 100000 deaths occurring during hospitalization, and approximately 1 of 3 patients hospitalized with CAP dying within 1 year.
Impact of a Rapid Respiratory Panel Test on Patient Outcomes
Beverly Barton Rogers,Prabhu Rv Shankar,Robert C. Jerris,David Kotzbauer,Evan J. Anderson,J. Renee’ Watson,Lauren A. O'Brien,Francine Uwindatwa,Kelly McNamara,James E. Bost +9 more
TL;DR: The RRP decreases the duration of antibiotic use, the length of inpatient stay, and the time in isolation, according to inpatients 3 months or older with an acute respiratory tract illness.
239
β-Lactam monotherapy vs β-lactam-macrolide combination treatment in moderately severe community-acquired pneumonia: a randomized noninferiority trial.
Nicolas Garin,Daniel Genné,Sebastian Carballo,Christian Chuard,Gerhardt Eich,Olivier Hugli,Olivier Lamy,Mathieu Nendaz,Pierre-Auguste Petignat,Thomas V. Perneger,Olivier Thierry Rutschmann,Laurent Seravalli,Stéphan Juergen Harbarth,Arnaud Perrier +13 more
TL;DR: Noninferiority of β-lactam monotherapy was found in patients hospitalized for moderately severe community-acquired pneumonia, but not in patients infected with atypical pathogens or with PSI category IV pneumonia.
237
Related Papers (5)
[...]
Raquel Belforti,Raquel Belforti,Tara Lagu,Tara Lagu,Sarah Haessler,Sarah Haessler,Peter K. Lindenauer,Peter K. Lindenauer,Penelope S. Pekow,Aruna Priya,Marya D. Zilberberg,Daniel J. Skiest,Daniel J. Skiest,Thomas L. Higgins,Thomas L. Higgins,Mihaela S. Stefan,Mihaela S. Stefan,Michael B. Rothberg +17 more