Journal Article10.1001/JAMA.1940.02810510038010
Orthostatic hypotension and orthostatic tachycardia: treatment with the head-up bed
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TL;DR: Orthostatic hypotension should be suspected whenever a patient has exhaustion in the morning which lessens during the day, whenever weakness, dimness of vision or syncope occurs on assumption of the erect posture and disappears on lying down, whenever episodes of syncope are inadequately explained and whenever there is diminished sweating.
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Abstract: Orthostatic hypotension is characterized chiefly by a sharp decrease in blood pressure when a patient afflicted with it stands. The blood pressure is ordinarily normal when the patient lies. If the blood pressure decreases to a low level, weakness and syncope result. Other relevant signs or symptoms are deficient sweating, either localized or generalized, secretion of larger amounts of urine when the patient is recumbent than when he is erect and in some cases a failure of the pulse rate to increase markedly when the patient assumes the erect posture. Orthostatic hypotension should be suspected whenever a patient has exhaustion in the morning which lessens during the day, whenever weakness, dimness of vision or syncope occurs on assumption of the erect posture and disappears on lying down, whenever episodes of syncope are inadequately explained and whenever there is diminished sweating. This condition has been considered by some to be the
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References
Benzedrine and paredrine in the treatment of orthostatic hypotension, with supplementary case report
TL;DR: In January, 1937, in a report1 of the experience with benzedrine in the treatment of orthostatic hypotension, it was pointed out that if amounts of either Benzedrine or ephedrine sufficiently enough to treat hypotension were sufficiently high, then the hypotension would be treatable.
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EFFECT OF PAREDRINOL (alpha-N-DIMETHYL-p-HYDROXYPHENETHYLAMINE) ON SODIUM NITRITE COLLAPSE AND ON CLINICAL SHOCK.
TL;DR: Paredrinol 1 (a-N-dimethyl-p-hydroxyphenethylamine) fulfilled several of the requirements of the ideal drug for the prevention of circulatory collapse and in that accompanying postural hypotension and acute infectious disease, and was investigated in the collapse induced by sodium nitrite.