Organoiridium complexes: anticancer agents and catalysts.
Zhe Liu,Peter J. Sadler +1 more
TL;DR: In this paper, a review of recent developments in organoiridium complexes is presented, including the development of half-sandwich pseudo-octahedral pentamethylcyclopentadienyl IrIII complexes with diamine ligands.
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Abstract: ConspectusIridium is a relatively rare precious heavy metal, only slightly less dense than osmium. Researchers have long recognized the catalytic properties of square-planar IrI complexes, such as Crabtree’s hydrogenation catalyst, an organometallic complex with cyclooctadiene, phosphane, and pyridine ligands. More recently, chemists have developed half-sandwich pseudo-octahedral pentamethylcyclopentadienyl IrIII complexes containing diamine ligands that efficiently catalyze transfer hydrogenation reactions of ketones and aldehydes in water using H2 or formate as the hydrogen source. Although sometimes assumed to be chemically inert, the reactivity of low-spin 5d6 IrIII centers is highly dependent on the set of ligands. Cp* complexes with strong σ-donor C∧C-chelating ligands can even stabilize IrIV and catalyze the oxidation of water. In comparison with well developed Ir catalysts, Ir-based pharmaceuticals are still in their infancy. In this Account, we review recent developments in organoiridium complexe...
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Citations
Endoplasmic reticulum stress: an arising target for metal-based anticancer agents
A. Paden King,Justin J. Wilson +1 more
TL;DR: A discussion on the perspectives and significance of using metal complexes as ER stress-inducing agents for the treatment of cancer is provided, along with a summary of structural trends that contribute to this type of biological activity.
146
Metal complexes as potential modulators of inflammatory and autoimmune responses
TL;DR: In this perspective, recent examples in the development of transition metal complexes as modulators of inflammatory and autoimmune responses are highlighted.
Metallodrugs in cancer nanomedicine.
Quim Peña,Alec Wang,Orysia Zaremba,Yang Shi,Hans W. Scheeren,Josbert M. Metselaar,Fabian Kiessling,Roger M. Pallares,Stefan Wuttke,Twan Lammers +9 more
TL;DR: A critical review of the opportunities and clinical challenges of metallodrugs, and the latest and most relevant nanomedicine formulations developed for metal complexes, to discuss how the rational combination of coordination chemistry with nanomedicsine technology can assist in promoting the clinical translation of meetallodrogs.
126
In-vitro and In-vivo Photocatalytic Cancer Therapy with Biocompatible Iridium(III) Photocatalysts
Can Huang,Chao Liang,Tumpa Sadhukhan,Samya Banerjee,Samya Banerjee,Zhongxian Fan,Tingxuan Li,Zhu Zilin,Pingyu Zhang,Krishnan Raghavachari,Huaiyi Huang +10 more
TL;DR: In this article, a photo-catalytic photocatalyst with strong light absorption, high turnover frequency, and excellent biocompatibility is reported, and the photo-induced intracellular redox imbalance and change in mitochondrial membrane potential resulted in necrosis and apoptosis of cancer cells.
121
Potent Half-Sandwich Iridium(III) Anticancer Complexes Containing C(∧)N-Chelated and Pyridine Ligands.
TL;DR: This class of organometallic Ir complexes has unusual features worthy of further exploration in the design of novel anticancer drugs, and displayed the highest anticancer activity.
121
References
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
TL;DR: It is argued that modulating the unique redox regulatory mechanisms of cancer cells might be an effective strategy to eliminate these cells.
5K
Organometallic Anticancer Compounds
TL;DR: The quest for alternative drugs to the well-known cisplatin and its derivatives, which are still used in more than 50% of the treatment regimes for patients suffering from cancer, is highly needed, and organometallic compounds have recently been found to be promising anticancer drug candidates.
1.5K
Reversible hydrogen storage using CO2 and a proton-switchable iridium catalyst in aqueous media under mild temperatures and pressures.
Jonathan F. Hull,Yuichiro Himeda,Wan-Hui Wang,Brian G. Hashiguchi,Roy A. Periana,David J. Szalda,James T. Muckerman,Etsuko Fujita +7 more
TL;DR: The first reversible and recyclable hydrogen storage system that operates under mild conditions using CO2, formate and formic acid is shown, which is energy-efficient and green because it operates near ambient conditions, uses water as a solvent, produces high-pressure CO-free hydrogen, and uses pH to control hydrogen production or consumption.
Catalytic Alkane Metathesis by Tandem Alkane Dehydrogenation-Olefin Metathesis
TL;DR: One example that achieves selectivity with respect to the distribution of product molecular weights is reported, in which n-decane is the predominant high-molecular-weight product of the metathesis of two moles of n-hexane.
568
Water exchange on metal ions: experiments and simulations
Lothar Helm,Andre E. Merbach +1 more
TL;DR: In this article, the authors demonstrate the complementary of experimental studies and computer simulations or quantum chemical calculations performed on the water exchange reaction between coordination shells around metal ions in aqueous solution.
494