Orbital metastases: diagnosis and course
TL;DR: In this article, a retrospective analysis of patients with orbital metastases managed in an ocular oncology unit showed that the median survival was 1.3 years, and no clinical factors correlated with prognosis.
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Abstract: AIMS—Three issues were investigated in adult outpatients with orbital metastases. One, how accurate are current diagnostic methods? Two, what is the survival associated with orbital metastases? Three, did any clinical factors correlate with prognosis in this patient cohort?
METHODS—Retrospective analysis of patients with orbital metastases managed in an ocular oncology unit.
RESULTS—11 of 31 (35%) patients had no known primary malignancy at the time of orbital diagnosis. In eight of 31 (26%) computed tomography and/or magnetic resonance imaging data did not yield the diagnosis of metastases. In 15 of 17 (88%) cases a fine needle aspiration biopsy was diagnostic. Several types of therapy were used. The median survival was 1.3 years.
CONCLUSION—Orbital metastases, even with newer diagnostic techniques can be difficult to diagnose. Management was based on location and extent of both orbital and systemic disease as well as vision. In most cases, orbital symptoms were palliated; however, survival was dismal. No clinical factor correlated with prognosis.
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Citations
Cancer metastatic to the orbit: the 2000 Robert M. Curts Lecture.
Jerry A. Shields,Carol L. Shields,Heather K. Brotman,Cynthia Carvalho,Noel Perez,Ralph C. Eagle +5 more
TL;DR: The most common primary cancers that metastasize to the orbit are breast, prostate gland, and lung cancer and the systemic prognosis is generally poor.
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Metastatic tumors of the orbit and ocular adnexa.
S. Mehdi Ahmad,Bita Esmaeli +1 more
TL;DR: The longer survival time for patients with breast carcinoma, the availability of novel targeted treatment options and new investigational agents, and advances in radiotherapy techniques may lead to better quality of life and preservation of ocular function for Patients with metastatic orbital tumors.
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MicroRNAs transported by exosomes in body fluids as mediators of intercellular communication in cancer
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TL;DR: This review focuses on miRNAs secreted via TR exosomes, which by acting in a paracrine or endocrine manner, facilitate a diversity of signaling mechanisms between cancer cells.
Metastatic melanoma in the eye and orbit.
Leonidas Zografos,Nicolas Ducrey,Donata Beati,Ann Schalenbourg,Barbara Spahn,Aubin Balmer,Chantal Bornet Othenin-Girard,Line Chamot,E. Egger +8 more
TL;DR: Metastatic melanomas to the eye and orbit are rare and generally occur in patients with disseminated metastases during the terminal stages of the disease, with a short life expectancy.
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Cancers of the eye
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