Optimal Medical Therapy With or Without Percutaneous Coronary Intervention to Reduce Ischemic Burden Results From the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) Trial Nuclear Substudy
Leslee J. Shaw,Daniel S. Berman,David J. Maron,G.B. John Mancini,Sean W. Hayes,Pamela M. Hartigan,William S. Weintraub,Robert A. O'Rourke,Marcin Dada,John A. Spertus,Bernard R. Chaitman,John D. Friedman,Piotr J. Slomka,Gary V. Heller,Guido Germano,Gilbert Gosselin,Peter B. Berger,William J. Kostuk,Ronald G. Schwartz,Merill L Knudtson,Emir Veledar,Eric R. Bates,Benjamin D. McCallister,Koon K. Teo,William E. Boden +24 more
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TL;DR: In COURAGE patients who underwent serial MPS, adding PCI to OMT resulted in greater reduction in ischemia compared with OMT alone, and the findings suggest a treatment target of ≥5% ischemic myocardium reduction with O MT with or without coronary revascularization.
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Abstract: Background— Extent and severity of myocardial ischemia are determinants of risk for patients with coronary artery disease, and ischemia reduction is an important therapeutic goal. The Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) nuclear substudy compared the effectiveness of percutaneous coronary intervention (PCI) for ischemia reduction added to optimal medical therapy (OMT) with the use of myocardial perfusion single photon emission computed tomography (MPS). Methods and Results— Of the 2287 COURAGE patients, 314 were enrolled in this substudy of serial rest/stress MPS performed before treatment and 6 to 18 months (mean=374±50 days) after randomization using paired exercise (n=84) or vasodilator stress (n=230). A blinded core laboratory analyzed quantitative MPS measures of percent ischemic myocardium. Moderate to severe ischemia encumbered ≥10% myocardium. The primary end point was ≥5% reduction in ischemic myocardium at follow-up. Treatment groups had similar ...
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Optimal medical therapy with or without PCI for stable coronary disease
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Comparison of the Short-Term Survival Benefit Associated With Revascularization Compared With Medical Therapy in Patients With No Prior Coronary Artery Disease Undergoing Stress Myocardial Perfusion Single Photon Emission Computed Tomography
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•Journal Article
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Guido Germano,Hosen Kiat,Paul B. Kavanagh,M Moriel,M. Mazzanti,Hsiao-Te Su,K. Van Train,Daniel S. Berman +7 more
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