Olfaction: diverse species, conserved principles.

TL;DR: It is proposed that the UBR box of UBR3 may recognize small compounds that modulate the targeting, by this E3, of its currently unknown substrates.

TL;DR: A brief survey and update of the most powerful and rapidly growing analytical techniques as used in marine biotechnology, together with some promising examples of less well known earlier stage methods which may make a bigger impact in the future.

TL;DR: This study investigates the electrophysiological responses of the clam osphradium to amino acids and alarm cues, revealing sensitivity to most proteinogenic amino acids, but not acidic amino acids or bile acids, and a lack of response to predator-released cues, suggesting alternative predator detection mechanisms.

TL;DR: Investigating whether two nocturnal bird species that are known to rely on olfactory cues have evolved a larger OR gene repertoire than their day-active, closest living relatives suggests ecological niche adaptations such as daily activity patterns may have shaped avian OR gene repertoires.

TL;DR: This work has cloned and characterized 18 different members of an extremely large multigene family that encodes seven transmembrane domain proteins whose expression is restricted to the olfactory epithelium and is likely to encode a diverse family of odorant receptors.

TL;DR: Using a combination of calcium imaging and single-cell RT-PCR to identify odorant receptors (ORs) for odorants with related structures but varied odors, it is found that one OR recognizes multiple odorants and that one odorant is recognized by multiple ORs, but that different odorants are recognized by different combinations of ORs.

TL;DR: This first comprehensive analysis of the genome sequence of the Brown Norway (BN) rat strain is reported, which is the third complete mammalian genome to be deciphered, and three-way comparisons with the human and mouse genomes resolve details of mammalian evolution.

TL;DR: A genetic approach is developed to visualize axons from olfactory sensory neurons expressing a given odorant receptor, as they project to the Olfactory bulb, which provides direct support for a model in which a topographic map of receptor activation encodes odor quality in the ofactory bulb.