Occupational solvent exposure and adult chronic lymphocytic leukemia: No risk in a population-based case-control study in four Nordic countries.
Madar Talibov,Anssi Auvinen,Elisabete Weiderpass,Johnni Hansen,Jan Ivar Martinsen,Kristina Kjærheim,Laufey Tryggvadottir,Eero Pukkala +7 more
TL;DR: Observed weak associations for methylene chloride, perchloroethylene, 1,1,1‐trichloroethane exposures, aliphatic and alicyclic hydrocarbons and toluene were not consistent across sexes, and showed no gradient with amount of exposure.
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Abstract: The aim of this study was to assess the effect of occupational solvent exposure on the risk of adult chronic lymphocytic leukemia (CLL). The current case-control study was nested in the Nordic Occupational Cancer Study (NOCCA) cohort. 20,615 CLL cases diagnosed in 1961-2005 in Finland, Iceland, Norway, and Sweden, and 103,075 population-based controls matched by year of birth, sex, and country were included. Occupational histories for cases and controls were obtained from census records in 1960, 1970, 1980/1981, and 1990. Exposure to selected solvents was estimated by using the NOCCA job-exposure matrix (NOCCA-JEM). Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated by using conditional logistic regression models. Overall, nonsignificant CLL risk elevations were observed for methylene chloride, perchloroethylene, and 1,1,1-trichloroethane. Compared to unexposed, significantly increased risks were observed for cumulative perchloroethylene exposure ≤13.3 ppm-years (OR = 1.85, 95% CI 1.16-2.96) and average life-time perchloroethylene exposure ≤2.5 ppm (1.61, 95% CI 1.01-2.56) among women, and cumulative methylene chloride exposure ≤12.5 ppm-years (OR = 1.19, 95% CI 1.01-1.41) and 12.5-74.8 ppm-years (OR = 1.23, 95% CI 1.01-1.51) among men in an analysis with 5 years lag-time, though without dose-response pattern. Decreased CLL risk was observed for aliphatic and alicyclic hydrocarbon solvents and toluene. This study did not support associations for solvent exposure and CLL. Observed weak associations for methylene chloride, perchloroethylene, 1,1,1-trichloroethane exposures, aliphatic and alicyclic hydrocarbons and toluene were not consistent across sexes, and showed no gradient with amount of exposure.
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Citations
A mixtures approach to solvent exposures and amyotrophic lateral sclerosis: a population-based study in Denmark
TL;DR: An increased risk of ALS in men exposed to multiple solvents, with the greatest influence being from methylene chloride is suggested, highlighting the need to utilize mixtures analysis when considering co-occurring exposures.
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Evaluation of the carcinogenicity of dichloromethane in rats, mice, hamsters and humans.
TL;DR: In this article, the authors have shown that DCM is a threshold carcinogen in mice, initiating carcinogenicity via the low affinity/high capacity GSTT1 pathway; a biotransformation pathway that becomes relevant only at high exposure concentrations.
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Bilateral breast implant associated chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL): A case report.
Patrick P. Bletsis,Laura E. Janssen,Otto Visser,Saskia R. Offerman,Michiel A. Tellier,Laurens Laterveer,Peter Houpt +6 more
TL;DR: Implant-associated breast lymphomas are rare and most are of T-cell lineage, whereas CLL is found the bone marrow and blood whereas SLL is predominantly found in the lymph nodes and spleen.
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Occupational risk variation of nasopharyngeal cancer in the Nordic countries
Timo Carpén,Evelina Gille,Lalle Hammarstedt-Nordenvall,Johnni Hansen,Sanna Heikkinen,Elsebeth Lynge,Jenny Selander,Ingrid Sivesind Mehlum,Johanna E. Torfadottir,Antti Mäkitie,Eero Pukkala +10 more
TL;DR: In this paper , the authors estimate occupational risk variation in the incidence of nasopharyngeal cancer (NPC) in a large population-based cohort of the Nordic Occupational Cancer (NOCCA) study.
References
Applied Logistic Regression.
TL;DR: Applied Logistic Regression, Third Edition provides an easily accessible introduction to the logistic regression model and highlights the power of this model by examining the relationship between a dichotomous outcome and a set of covariables.
40.1K
The completeness of the Swedish Cancer Register: a sample survey for year 1998.
TL;DR: The overall completeness of the SCR is high and comparable to other high quality registers in Northern Europe, and the degree of underreporting is site specific, increases with age, and does not seem to be random.
1.2K
Data quality at the Cancer Registry of Norway: An overview of comparability, completeness, validity and timeliness
Inger Kristin Larsen,Milada Cvancarova Småstuen,Tom Børge Johannesen,Frøydis Langmark,Donald Maxwell Parkin,Freddie Bray,Bjørn Møller +6 more
TL;DR: The routines in place at the CRN yields comparable data that can be considered reasonably accurate, close-to-complete and timely, thereby justifying the policy of the reporting of annual incidence one year after the year of diagnosis.
836
Occupation and cancer – follow-up of 15 million people in five Nordic countries
Eero Pukkala,Jan Ivar Martinsen,Elsebeth Lynge,Holmfridur Gunnarsdottir,Pär Sparén,Laufey Tryggvadottir,Elisabete Weiderpass,Kristina Kjærheim +7 more
TL;DR: Mesothelioma was the cancer type showing the largest relative differences between the occupations, and plumbers, seamen and mechanics were the occupations with the highest risk in the present study.