Journal Article10.1016/J.BIOMATERIALS.2014.01.019
Nucleolin-targeting liposomes guided by aptamer AS1411 for the delivery of siRNA for the treatment of malignant melanomas
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TL;DR: Results suggested that the new nucleolin-targeted siRNA delivery system by AS1411 may have the potential for the treatment of melanoma.
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About: This article is published in Biomaterials. The article was published on 01 Apr 2014. The article focuses on the topics: Nucleolin & Cationic liposome.
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Citations
A Dual Targeting Magnetic Nanoparticle for Human Cancer Detection
Siwen Wu,Xiyu Liu,Jian He,Huiling Wang,Yiqun Luo,Wenlin Gong,Yanmei Li,Yong Huang,Liping Zhong,Yongxiang Zhao +9 more
TL;DR: A dual-targeting magnetic nanoprobe with high-purity LECs from tumor tissues was successfully developed, providing a basis for clinical application of L ECs in colorectal cancer treatment as well as in early clinical diagnosis using bimodal imaging.
Aptamer and Phosphorothioated DNA Engineered Liposomes as a Targeted Intracellular Protein Delivery System
Jiamei Li,An Yan,Di Li +2 more
TL;DR: Researchers developed a targeted protein delivery system using aptamer-capped phosphorothioated DNA and liposomes, achieving effective cancer cell inhibition in vitro and in vivo with high biocompatibility and specificity.
Exploring the therapeutic modalities of targeted treatment approach for skin carcinoma: cutting-edge strategies and key insights
Vaibhavi Meghraj Desai,Pragati Kumbhar,Akanksha Yogesh Kadam,Jayanti Swarup,Sakshi Priya,Ankit Jain,Gautam Singhvi +6 more
TL;DR: This study explores cutting-edge targeted treatment approaches for skin carcinoma, focusing on nano-sized delivery systems and nanoparticles that improve treatment outcomes while minimizing side effects and tissue damage.
Nanoscale mapping of nucleolin–aptamer interactions on lung cancer cells reveals binding affinity hierarchy and spatial heterogeneity
Longyun Chen,Rong-Rong Feng,Qianhui Xu,Huaiwei Zhang,You Sun,Peng Weijie,Weidong Zhao,Feng Jiang,Longyun Chen,Rong-Rong Feng,Qianhui Xu,Huaiwei Zhang,You Sun,Peng Weijie,Weidong Zhao,Feng Jiang +15 more
Abstract: Atomic force microscopy probes nucleolin-aptamer interactions on lung cancer cells at single molecule resolution, measuring binding forces in piconewton and electrical properties with 0.1 mV sensitivity.
Drug Metabolism and Pharmacokinetics
14 Feb 2024
TL;DR: This book provides comprehensive information on drug metabolism and pharmacokinetics for drug discovery and development, covering various pharmacokinetic parameters and recent advances in the field.
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