Nucleolin-targeting liposomes guided by aptamer AS1411 for the delivery of siRNA for the treatment of malignant melanomas

TL;DR: The modification strategies for enhancing the metabolic stabilities and pharmacokinetics of aptamer drug candidates are reviewed. Chemical modifications can improve the metabolic stability and prolong the half-life of aptamers.

TL;DR: The thesis helps to unravel the function of T lymphoma invasion and metastasis protein (TIAM1) and nucleolin, a nucleolar protein in retinoblastoma tumorigenesis and use of aptamer for blocking the miRNA-17-92 cluster maturation.

TL;DR: G-quadruplex-based aptamers are highly selective molecular probes with therapeutic potential in various applications. Many aptamers exhibit G-quadruplex structures, highlighting their importance in drug design and development.

TL;DR: The basic characteristics of the EPR effect, particularly the factors involved, are described, as well as its modulation for improving delivery of macromolecular drugs to the tumor.

TL;DR: In this paper, the authors proposed a passive targeting mechanism, active targeting strategies using ligands or antibodies directed against selected tumor targets amplify the specificity of these therapeutic nanoparticles, enabling them to carry their loaded active drugs to cancer cells by selectively using the unique pathophysiology of tumors.

TL;DR: The magnitude of the cytotoxic effects of all polymers were found to be time- and concentration dependent and the molecular weight as well as the cationic charge density of the polycations were confirmed as key parameters for the interaction with the cell membranes and consequently the cell damage.

TL;DR: Multifunctional and multiplex nanoparticles are now being actively investigated and are on the horizon as the next generation of nanoparticles, facilitating personalized and tailored cancer treatment.