Journal Article10.1016/J.BIOMATERIALS.2014.01.019
Nucleolin-targeting liposomes guided by aptamer AS1411 for the delivery of siRNA for the treatment of malignant melanomas
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TL;DR: Results suggested that the new nucleolin-targeted siRNA delivery system by AS1411 may have the potential for the treatment of melanoma.
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About: This article is published in Biomaterials. The article was published on 01 Apr 2014. The article focuses on the topics: Nucleolin & Cationic liposome.
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Citations
Fabrication of aptamer modified TiO2 nanofibers for specific capture of circulating tumor cells.
TL;DR: The potential of the TiO2-BSA-biotin-AS1411 nanofiber substrate as a highly efficient platform to realize the selective and specific capture of rare CTCs in the clinical settings is highlighted.
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Cell-specific aptamers as potential drugs in therapeutic applications: A review of current progress.
TL;DR: In this article , the authors reviewed the multidimensional research progress made in terms of their classification, modification, and application, focusing on the increasing research attraction of cell state improving helpers and cell recruitment mediators in the improvement of cellular microenvironments to achieve successful disease therapy.
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Multifunctional Gold Nanoparticles Overcome MicroRNA Regulatory Network Mediated-Multidrug Resistant Leukemia
Rong Deng,Bai Ji,Hongliang Yu,Wei Bao,Zhuoqi Yang,Ying Yu,Yahan Cui,Yangyang Du,Meiyu Song,Shujun Liu,Kamel Meguellati,Fei Yan +11 more
TL;DR: These findings provide proof of concept that this novel drug delivery system can precisely reverse the multidrug resistant leukemia phenotype based on preclinical models of leukemia, providing the framework for future clinical trials aimed at overcoming drug resistance and improving patient outcome.
Nucleolin Overexpression Confers Increased Sensitivity to the Anti-Nucleolin Aptamer, AS1411
TL;DR: It is shown that constitutive overexpression of nucleolin confers increased sensitivity to the growth inhibitory effects of AS1411, suggesting a feedback loop with important implications for the clinical use of As1411.
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Application of Non-Viral Vectors in Drug Delivery and Gene Therapy.
Shuaikai Ren,Mengjie Wang,Chunxin Wang,Yan Wang,Changjiao Sun,Zhanghua Zeng,Haixin Cui,Xiang Zhao +7 more
TL;DR: Non-viral vectors are widely developed and applied in clinical practice due to their low immunogenicity, good biocompatibility, easy synthesis and modification, and low cost of production as mentioned in this paper.
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