Patent
Nucleic acids, proteins and antibodies
Craig A. Rosen,Steven M. Ruben +1 more
- 10 Aug 2001
829
TL;DR: In this article, isolated nucleic acid molecules are provided encoding novel polypeptides, and recombinant and synthetic methods for producing human polynucleotides and/or polypeps and antibodies are provided.
read more
Abstract: The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Patent
Methods for identification, and compounds useful for the treatment of degenerative & inflammatory diseases
Reginald Christophe Xavier Brys,Nick Vandeghinste,Peter Herwig Maria Tomme +2 more
- 14 Jun 2005
TL;DR: In this paper, in vivo and in vitro methods, agents and compound screening assays for inhibiting extra-cellular matrix degradation, including joint degenerative inhibiting and/or anti-inflammatory pharmaceutical compositions, and the use thereof in treating or preventing a disease involving extracellular matrices degradation in a subject.
6
Patent
Gene and polypeptide relating to human colon cancer
Yoichi Furukawa,Nakamura Yusuke,Hideaki Tawara,Takuya Tsunoda,祐輔 中村,洋一 古川,秀晃 田原,卓也 角田 +7 more
- 18 Aug 2011
TL;DR: In this paper, new human genes RNF43 as well as CXADRL1 and GCUD1, whose expression is markedly elevated in colorectal cancers, compared to corresponding non-cancerous tissues, were provided, which can be used in the diagnosis of a cell proliferative disease and as target molecules for developing drugs against the disease.
6
Patent
Polynucleotide encoding a novel immunoglobulin superfamily member, apex4, and variants and splice variants thereof
Joshua Finger
- 22 Mar 2002
TL;DR: In this article, the authors provided polynucleotides encoding APEX4 polypeptides, fragments and homologues thereof, and diagnostic and therapeutic methods for applying these novel polynuclotides to the diagnosis, treatment, and/or prevention of various diseases and disorders.
6
Patent
Solid Forms of a Thiophosphoramidate Nucleotide Prodrug
Anuj K. Kuldipkumar,Ales Medek,Ferris Lori Ann,Praveen Mudunuri,Young Chun Jung,David Willcox,Waldo Michael,William A. Nugent +7 more
- 11 Mar 2013
TL;DR: In this paper, solid state forms of 2.C-methyluridine-5′-(O-phenyl-N-S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate were used to treat or ameliorate diseases and conditions.
6
Patent
Methods of treating overweight and obesity
Preston Klassen,Kristin Taylor +1 more
- 05 Jun 2013
TL;DR: In this article, the authors present compositions, kits, uses, systems and methods for treating overweight and obesity using naltrexone plus bupropion, preferably in combination with a comprehensive web-based and/or telephone-based weight management program, and preferably in subjects at increased risk of adverse cardiovascular outcomes.
6
References
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.
Charles K. Stover,X. Q. Pham,A. L. Erwin,S. D. Mizoguchi,Paul Warrener,Mark J. Hickey,Fiona S. L. Brinkman,W. O. Hufnagle,D. J. Kowalik,Lagrou Mj,R. L. Garber,L. Goltry,E. Tolentino,S. Westbrock-Wadman,Ying Yuan,L. L. Brody,S. N. Coulter,K. R. Folger,Arnold Kas,K. Larbig,R. Lim,Kelly D. Smith,David H. Spencer,Gane Ka-Shu Wong,Z. Wu,Ian T. Paulsen,Ian T. Paulsen,Jonathan Reizer,Milton H. Saier,Robert E. W. Hancock,Stephen Lory,Maynard V. Olson +31 more
TL;DR: It is proposed that the size and complexity of the P. aeruginosa genome reflect an evolutionary adaptation permitting it to thrive in diverse environments and resist the effects of a variety of antimicrobial substances.
Patent
Reusable medication delivery pen
David Balkwill
- 04 Feb 1992
TL;DR: An injection device medication delivery pen is provided for injecting fluids such as insulin within body tissue as mentioned in this paper, which includes a housing, a piston rod movably mounted within the housing, and a dose setting mechanism for controlling the movement of the piston rod with respect to a fluid containing cartridge removably positioned within the house.
327
Patent
Expressed sequence tags and encoded human proteins
Jean-Baptiste Dumas Milne Edwards,Aymeric Duclert,Jean-Yves Giordano +2 more
- 21 Feb 2000
TL;DR: In this article, the sequences of 5′ ESTs derived from mRNAs encoding secreted proteins are disclosed and used in diagnostic, forensic, gene therapy, and chromosome mapping procedures.
302
Transcriptional downregulation of gap-junction proteins blocks junctional communication in human mammary tumor cell lines.
TL;DR: Cx26 and Cx43 are both downregulated in tumor cells but respond differentially to some signals, suggesting that modulation of gap-junctional activity by drug therapy may have useful clinical applications in cancer.
267
Patent
Cloning by complementation and related processes
Michael Wigler,John J. Colicelli +1 more
- 19 Apr 1991
TL;DR: In this paper, the authors present methods for detecting mammalian genes encoding proteins which can function in microorganisms, particularly yeast, to modify, complement, or suppress a genetic defect associated with an identifiable phenotypic alteration or characteristic in the microorganism.
196
Related Papers (5)
Y. Tom Tang,Chenghua Liu,Radoje T. Drmanac +2 more
- 10 Dec 2002
Nils Lonberg,Robert M. Kay +1 more
- 28 Aug 1991