Patent
Nucleic acids, proteins and antibodies
Craig A. Rosen,Steven M. Ruben +1 more
- 10 Aug 2001
829
TL;DR: In this article, isolated nucleic acid molecules are provided encoding novel polypeptides, and recombinant and synthetic methods for producing human polynucleotides and/or polypeps and antibodies are provided.
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Abstract: The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
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References
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.
Charles K. Stover,X. Q. Pham,A. L. Erwin,S. D. Mizoguchi,Paul Warrener,Mark J. Hickey,Fiona S. L. Brinkman,W. O. Hufnagle,D. J. Kowalik,Lagrou Mj,R. L. Garber,L. Goltry,E. Tolentino,S. Westbrock-Wadman,Ying Yuan,L. L. Brody,S. N. Coulter,K. R. Folger,Arnold Kas,K. Larbig,R. Lim,Kelly D. Smith,David H. Spencer,Gane Ka-Shu Wong,Z. Wu,Ian T. Paulsen,Ian T. Paulsen,Jonathan Reizer,Milton H. Saier,Robert E. W. Hancock,Stephen Lory,Maynard V. Olson +31 more
TL;DR: It is proposed that the size and complexity of the P. aeruginosa genome reflect an evolutionary adaptation permitting it to thrive in diverse environments and resist the effects of a variety of antimicrobial substances.
Patent
Reusable medication delivery pen
David Balkwill
- 04 Feb 1992
TL;DR: An injection device medication delivery pen is provided for injecting fluids such as insulin within body tissue as mentioned in this paper, which includes a housing, a piston rod movably mounted within the housing, and a dose setting mechanism for controlling the movement of the piston rod with respect to a fluid containing cartridge removably positioned within the house.
327
Patent
Expressed sequence tags and encoded human proteins
Jean-Baptiste Dumas Milne Edwards,Aymeric Duclert,Jean-Yves Giordano +2 more
- 21 Feb 2000
TL;DR: In this article, the sequences of 5′ ESTs derived from mRNAs encoding secreted proteins are disclosed and used in diagnostic, forensic, gene therapy, and chromosome mapping procedures.
302
Transcriptional downregulation of gap-junction proteins blocks junctional communication in human mammary tumor cell lines.
TL;DR: Cx26 and Cx43 are both downregulated in tumor cells but respond differentially to some signals, suggesting that modulation of gap-junctional activity by drug therapy may have useful clinical applications in cancer.
267
Patent
Cloning by complementation and related processes
Michael Wigler,John J. Colicelli +1 more
- 19 Apr 1991
TL;DR: In this paper, the authors present methods for detecting mammalian genes encoding proteins which can function in microorganisms, particularly yeast, to modify, complement, or suppress a genetic defect associated with an identifiable phenotypic alteration or characteristic in the microorganism.
196
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