Nucleated red blood cells are a direct response to mediators of inflammation in newborns with early-onset neonatal sepsis.
Antonette T. Dulay,Irina A. Buhimschi,Guomao Zhao,Guoyang Luo,Sonya S. Abdel-Razeq,Michael Cackovic,Victor A. Rosenberg,Christian M. Pettker,Stephen F. Thung,Mert Ozan Bahtiyar,Vineet Bhandari,Catalin S. Buhimschi +11 more
70
TL;DR: In the setting of inflammation-associated preterm birth and in the absence of hypoxia, elevations in NRBCs in the early neonatal period may be a direct response of exposure to inflammatory mediators in utero.
read more
About: This article is published in American Journal of Obstetrics and Gynecology. The article was published on 01 Dec 2007. and is currently open access. The article focuses on the topics: Chorioamnionitis & Neonatal sepsis.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
The fetal inflammatory response syndrome: the origins of a concept, pathophysiology, diagnosis, and obstetrical implications
Eun Jung Jung,Roberto Romero,Lami Yeo,Ramiro Diaz-Primera,Julio Marin-Concha,Robert Para,Ashley M. Lopez,Percy Pacora,Nardhy Gomez-Lopez,Bo Hyun Yoon,Chong Jai Kim,Stanley M. Berry,Chaur-Dong Hsu +12 more
TL;DR: The evidence so far suggests that FIRS may compound the effects of immaturity and neonatal inflammation, thus increasing the risk of neonatal complications and long-term morbidity, and modulation of a dysregulated fetal inflammatory response by the administration of antimicrobial agents, anti-inflammatory agents, or cell-based therapy holds promise to reduce infant morbidity and mortality.
171
A “multi-hit” model of neonatal white matter injury: cumulative contributions of chronic placental inflammation, acute fetal inflammation and postnatal inflammatory events
Steven J. Korzeniewski,Roberto Romero,Josepf Cortez,Athina Pappas,Athina Pappas,Alyse G. Schwartz,Chong Jai Kim,Jung Sun Kim,Yeon Mee Kim,Bo Hyun Yoon,Tinnakorn Chaiworapongsa,Tinnakorn Chaiworapongsa,Sonia S. Hassan,Sonia S. Hassan +13 more
TL;DR: Chronic placental inflammation, acute fetal inflammation, and neonatal inflammation-initiating illness seem to interact in contributing risk information and/or directly damaging the developing brain of newborns delivered very preterm.
104
Hematologic profile of the fetus with systemic inflammatory response syndrome.
Roberto Romero,Zeynep Alpay Savasan,Tinnakorn Chaiworapongsa,Stanley M. Berry,Juan Pedro Kusanovic,Sonia S. Hassan,Bo Hyun Yoon,Samuel S. Edwin,Moshe Mazor +8 more
TL;DR: The hematologic profile of the human fetus with FIRS is characterized by significant changes in the total WBC and neutrophil counts, and the NRBC count in fetuses with FIRs tends to be higher than fetuses without FIRS.
Chorioamnionitis and Risk for Maternal and Neonatal Sepsis: A Systematic Review and Meta-analysis.
TL;DR: In this paper, the risk of maternal and neonatal sepsis associated with chorioamnionitis was estimated based on 1,251 studies and a meta-analysis was conducted.
74
Using proteomics in perinatal and neonatal sepsis: hopes and challenges for the future.
Catalin S. Buhimschi,Vineet Bhandari,Yiping W. Han,Antonette T. Dulay,Margaret A. Baumbusch,Joseph A. Madri,Irina A. Buhimschi +6 more
TL;DR: Proteomics offers the opportunity for detecting fetuses at risk of sepsis and neurological injury by identifying proteomic biomarkers of inflammation associated with increased inflammatory status of the fetus at birth.
62
References
The neonatal blood count in health and disease.I. Reference values for neutrophilic cells
TL;DR: Reference ranges for absolute total neutrophil/mm3, absolute immature neutrophils/ mm3, and the fraction of immature to total neutophils (I:T proportion) during the first 28 days of life are developed from 585 peripheral blood counts obtained from 304 normal neonates and 320 counts from 130 neonates with perinatal complications.
809
A Population-Based Comparison of Strategies to Prevent Early-Onset Group B Streptococcal Disease in Neonates
Stephanie J. Schrag,Elizabeth R. Zell,Ruth Lynfield,Aaron Roome,Kathryn E. Arnold,Allen S. Craig,Lee H. Harrison,Arthur Reingold,Karen Stefonek,Glenda Smith,Melanie Gamble,Anne Schuchat +11 more
TL;DR: Routine screening for group B streptococcus during pregnancy prevents more cases of early-onset disease than the risk-based approach, and recommendations that endorse both strategies as equivalent warrant reconsideration.
647
Early diagnosis of neonatal sepsis using a hematologic scoring system.
TL;DR: The hematologic scoring system should improve the diagnostic accuracy of the complete blood cell count as a screening test for sepsis and could simplify and standardize the interpretation of this global test.
418
Nucleated red blood cells in the fetus and newborn.
TL;DR: There is a large overlap between the nRBC values found after acute, subacute, and chronic asphyxia; asphyxi of any duration does not always cause an increased nR BC count, and extreme increases may be found without asphyxiation.
252
Nucleated red blood cells: A marker for fetal asphyxia?
TL;DR: The data suggest that cord blood nucleated red blood cells could assist in the timing of fetal neurologic injury, and in general, the closer the birth was to the asphyxial event, the lower was the number of nucleatedred blood cells.
112