Nrf2-ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases.

TL;DR: The evidence for oxidative stress in neurodegeneration is reviewed and how this relates to other cellular events in the emerging roadmap leading to neurodegenesis is reviewed.

TL;DR: NRF2 represents one of the first targets fully embraced by classic and systems medicine approaches to facilitate both drug development and drug repurposing by focusing on a set of disease phenotypes that appear to be mechanistically linked.

TL;DR: The interplay between the NRF2-ARE system and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-ĸB, a protein complex that controls cytokine production and cell survival), has been further investigated in relation to neurodegenerative and neuroinflammatory disorders.

TL;DR: In this paper , the authors describe the signaling pathways involved in ischemic stroke and categorize them based on the pathophysiological processes they participate in, and summarize the therapeutic approaches targeted various pathophysiology.

TL;DR: Low and high doses of curcumin significantly lowered oxidized proteins and interleukin-1β, a proinflammatory cytokine elevated in the brains of these mice, and shows promise for the prevention of Alzheimer's disease.

TL;DR: Early hallucinations and akinetic-dominant PD were associated with an increased risk of dementia, and more than three quarters of this representative PD cohort developed dementia during the 8-year study period.

TL;DR: It is proposed that Keap1 is a component of a novel E3 ubiquitin ligase complex that is specifically targeted for inhibition by both chemopreventive agents and oxidative stress.

TL;DR: The genetics of these familial forms of Alzheimer's and Parkinson's disease are examined to improve understanding of the pathobiology of the more common, sporadic forms of the diseases.