Novel p2x7r antagonists and their use

TL;DR: In this article, the authors defined a class of heterocyclic amide derivatives of formula (I), where R1, R2, R3, R4, R5, n, m, p and X are defined in the description, their preparation and their use as pharmaceutically active compounds.

TL;DR: In this article, the indole carboxamide derivatives of formula (I), (I) wherein R1, R 2, R 3, R 4, R5 and R6 are as defined in the description, their preparation and their use as pharmaceutically active compounds.

TL;DR: In this paper, a method for treating or preventing age-related macular degeneration (AMD) in a patient subject to, or symptomatic of the disease, wherein the method comprises restoring normal lysosomal pH (pHL), or acidifying an abnormally elevated pHL, thus decreasing or preventing a damaging accumulation of lipofuscin or waste products in the retinal pigment epithelium (RPE) cells of the patient.

TL;DR: The present paper relates to quinoline compounds, and pharmaceutically acceptable compositions thereof, useful as antagonists of P2X7, and for the treatment of P 2X7-related disorders.

TL;DR: In this paper, the authors provide compounds of formula (IA), processes for their preparation, pharmaceutical compositions containing them, and their use in therapy, as well as their application in medical applications.

TL;DR: The extensive use of high-throughput screening approaches, utilising diverse compound library sources, has lead to the identification of two important lead series (adamantane and benzenamide derivatives) acting on P2X7.

TL;DR: In this article, the authors defined compounds of formula (I), or a pharmaceutically acceptable salt thereof, wherein A represents a group (II), (III), (IV) or (V), and A, Ar2, n, R1, R2, R3, R4 and R5 are as defined in the specification; a process for their preparation; pharmaceutical compositions containing them; and their use in therapy.

TL;DR: In this article substituted phenyl compounds of general formula (I) are defined in the specification, a process for their preparation, pharmaceutical compositions containing them, and their use in therapy.