Novel mouse models of hepatic artery infusion
Minhyung Kim,Daniel T. Fisher,Colin A. Powers,Emmanuel Gabriel,Alexis M. Korman,Sandra Sexton,Andrei V. Gudkov,Joseph J. Skitzki +7 more
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TL;DR: The described techniques serve as a reproducible platform for the identification and characterization of therapeutics for diverse metastatic liver tumors with low mortality, better drug delivery, and preserved physiologic liver function compared with the HA model.
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About: This article is published in Journal of Surgical Research. The article was published on 01 Nov 2017. and is currently open access. The article focuses on the topics: Liver function & Superior pancreaticoduodenal artery.
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Chemoembolizing hepatocellular carcinoma with microsphere cored with arsenic trioxide microcrystal.
Degang Kong,Degang Kong,Tao Jiang,Tao Jiang,Jian Liu,Xinyi Jiang,Bei Liu,Cheng Lou,Baobing Zhao,Steven L. Carroll,Gong Feng +10 more
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Microsurgical Technique of Locoregional Injection into the Hepatic Artery in Tumor-Bearing Mice.
TL;DR: The experimental hepatic arterial injection in mice is a feasible but demanding microsurgical procedure whose choice of subsequent operation steps is dependent on the vascular anatomy of the hepatic artery which has two major variations in mice.
4
An implanted port-catheter system for repeated hepatic arterial infusion of low-density lipoprotein-docosahexaenoic acid nanoparticles in normal rats: A safety study.
Yuzhu Wang,Junjie Li,Indhumathy Subramaniyan,Gonçalo Vale,Jaideep Chaudhary,Arnida Anwar,Mary Wight-Carter,Jeffrey G. McDonald,William C. Putnam,Tao Qin,Hongwei Zhang,Ian R. Corbin +11 more
TL;DR: The findings indicate that repeated HAI of LDL-DHA nanoparticles is not only well tolerated and safe in the rat, but may also be protective to the liver.
3
A Translational Hepatic Artery Infusion (HAI) Model for Hepatocellular Carcinoma in Woodchucks.
Minhyung Kim,Colin A. Powers,Leslie Curtin,Daniel T. Fisher,Sandra Sexton,Katerina Gurova,Joseph J. Skitzki,Renuka Iyer +7 more
TL;DR: HAI via GDA was a feasible and reproducible approach with low morbidity and mortality in woodchucks and serves as a reliable platform for the identification and characterization of therapeutics for HCC.
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The greater vulnerability of bile duct cells to reoxygenation injury than to anoxia. Implications for the pathogenesis of biliary strictures after liver transplantation.
TL;DR: The hypothesis that reoxygenation injury during liver preservation leads to bile duct injury during Liver transplantation is supported.
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