Journal Article10.1016/S1043-2760(00)00357-X
Novel glucocorticoid receptor coactivator effector mechanisms
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TL;DR: The emerging picture shows coactivators as flexible, but precise, coordinators of complex and dynamic networks, in which transcriptional regulation by GR and other NRs is linked to other signaling pathways.
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Abstract: Glucocorticoids regulate numerous distinct physiological processes, most of which rely on the ability of the hormone-bound glucocorticoid receptor (GR) to change the expression of target genes in a cell- and promoter-dependent manner The transcriptional activity of GR depends on coactivators that regulate transcription by remodeling chromatin or by facilitating the recruitment of the basal transcriptional machinery Coactivators are often part of multiprotein complexes that are not specific for GR but also mediate the activity of other nuclear receptors (NRs) and unrelated transcription factors Surprisingly, recent results reveal that the activity of coactivators might contribute to the receptor, promoter and cell specificity of NR action The emerging picture shows coactivators as flexible, but precise, coordinators of complex and dynamic networks, in which transcriptional regulation by GR and other NRs is linked to other signaling pathways
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Citations
The biology of the glucocorticoid receptor: New signaling mechanisms in health and disease
TL;DR: In this article, the authors discuss the origin and molecular properties of the glucocorticoid receptor (GR) isoforms and their contribution to the specificity and sensitivity of glucoc corticoid signaling in healthy and diseased tissues.
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Corticosteroids: Mechanisms of Action in Health and Disease.
TL;DR: An overview of the molecular mechanisms that regulate glucocorticoid actions is provided, the dynamic nature of hormone signaling is highlighted, and the molecular properties of the GR isoforms are discussed.
Glucocorticoid receptor control of transcription: precision and plasticity via allostery
TL;DR: Evidence suggests that context-driven plasticity is conferred by the integration of multiple signals, each serving as an allosteric effector of GR conformation, a key determinant of regulatory complex composition and activity.
Molecular mechanisms of glucocorticoid action and resistance.
TL;DR: The mechanism of action of this ligand-inducible transcription factor, NF-kappa B, is discussed, focusing on mechanisms of glucocorticoid resistance.
436
Glucocorticoids in T cell apoptosis and function.
TL;DR: This review summarizes the present knowledge on GC action, the mechanisms employed to induce apoptosis and the currently discussed models of how they may participate in thymocyte development.
References
An Additional Region of Coactivator GRIP1 Required for Interaction with the Hormone-binding Domains of a Subset of Nuclear Receptors
TL;DR: Another region of coactivator GRIP1 (amino acids 1011–1121), called the auxiliary NID (NIDaux), is required in vitro and in vivo for efficient interaction with a subset of NRs, including the glucocorticoid receptor (GR), androgen receptor, and retinoic acid receptor α.
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Mouse steroid receptor coactivator-1 is not essential for peroxisome proliferator-activated receptor α-regulated gene expression
Chao Qi,Yijun Zhu,Jie Pan,Anjana V. Yeldandi,M. Sambasiva Rao,Nobuyo Maeda,V. Subbarao,Sujata Pulikuri,Takashi Hashimoto,Janardan K. Reddy +9 more
TL;DR: The results indicate that SRC-1 is not essential for PPARalpha-mediated transcriptional activation in vivo and suggest redundancy in nuclear receptor coactivators.
80
Conditional modulation of glucocorticoid receptor activities by CREB-binding protein (CBP) and p300
TL;DR: It is shown that one of the major coactivators of the glucocorticoid receptor (GR), CREB-binding protein (CBP), can also function conditionally as a negative regulator of its activities, and that CBP and p300 may function additively or antagonistically to each other depending on their relative concentrations and type of target tissue.
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Mutagenesis of the glucocorticoid receptor in mice.
TL;DR: To analyze molecular mechanisms of glucocorticoid receptor action in vivo a point mutation has been introduced into the mouse genome which allows to separate DNA- binding-dependent from DNA-binding-independent actions of the receptor.
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Nuclear Factor I-mediated Repression of the Mouse Mammary Tumor Virus Promoter Is Abrogated by the Coactivators p300/CBP and SRC-1
TL;DR: In this paper, the authors used transient transfection assays to assess transcriptional modulation by NFI proteins on the NFI-dependent mouse mammary tumor virus (MMTV) promoter.
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