Journal Article10.1016/J.BMCL.2020.127659
Novel deoxyvasicinone and tetrahydro-beta-carboline hybrids as inhibitors of acetylcholinesterase and amyloid beta aggregation.
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TL;DR: A novel series of deoxyvasicinone-tetrahydro-beta-carboline hybrids synthesized and evaluated as acetylcholinesterase (AChE) and β-amyloid peptide (Aβ) aggregation inhibitors for the treatment of Alzheimer's disease revealed that they had multifunctional profiles, including AChE inhibition, Aβ1-42 aggregation inhibition, and neuroprotective properties.
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About: This article is published in Bioorganic & Medicinal Chemistry Letters. The article was published on 15 Dec 2020. The article focuses on the topics: Acetylcholinesterase & Amyloid beta.
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Rational Design of a Structural Framework with Potential Use to Develop Chemical Reagents that Target and Modulate Multiple Facets of Alzheimer’s Disease
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A review of synthetic bioactive tetrahydro-β-carbolines: A medicinal chemistry perspective.
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In Vitro Anticancer Activity of Methanolic Extract of Justicia adhatoda Leaves with Special Emphasis on Human Breast Cancer Cell Line
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A Systemic Review for Ethnopharmacological Studies on <i>Isatis indigotica</i> Fortune: Bioactive Compounds and their Therapeutic Insights
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Design, combinatorial synthesis and cytotoxic activity of 2-substituted furo[2,3-d]pyrimidinone and pyrrolo[2,3-d]pyrimidinone library.
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