Open AccessDissertation
Novel approach to cancer therapeutics using comparative cancer biology
Bhindu Revi
- 30 Jun 2018
4
About: The article was published on 30 Jun 2018. and is currently open access. The article focuses on the topics: Cancer & Ganetespib.
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Citations
Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition
Mikko Taipale,Irina Krykbaeva,Martina Koeva,Can Kayatekin,Kenneth D. Westover,Georgios I. Karras,Susan Lindquist,Susan Lindquist +7 more
- 01 Aug 2012
TL;DR: The results establish HSP90 client recognition as a combinatorial process: CDC37 provides recognition of the kinase family, whereas thermodynamic parameters determine client binding within the family.
31
RanGTPase : a candidate for myc-mediated cancer progression
Hiu-Fung Yuen,Vignesh Gunasekharan,Kai-Kumar Chan,Shu-Dong Zhang,Angela Platt-Higgins,Kathy Gately,Kenneth J. O'Byrne,Dean A. Fennell,Patrick G. Johnston,Philip S. Rudland,Mohamed El-Tanani +10 more
- 01 Jan 2013
TL;DR: It is suggested that Ran is required for and is a potential therapeutic target of Myc-driven cancer progression in both breast and lung cancers.
27
Correction: Molecular Mechanism of Mutant p53 Stabilization: The Role of HSP70 and MDM2
Milena Wiech,Maciej B. Olszewski,Zuzanna Tracz-Gaszewska,Bartosz Wawrzynow,Maciej Zylicz,Alicja Zylicz +5 more
TL;DR: There is a white circle in Figure 6 that was erroneously introduced into a panel on the left side and the following link provides the correct version of Figure 6.
16
Stimulating immune responses to fight cancer: Basic biology and mechanisms
Kenneth J. O'Byrne,Kenneth J. O'Byrne,Kenneth J. O'Byrne +2 more
- 01 Jan 2015
TL;DR: In this paper, a balance between stimulatory and inhibitory signals regulates the immune response to cancer, which contributes to immune resistance, especially against tumor antigen-specific T-cells.
3
References
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TL;DR: The demonstration of a complex interplay between Hsp90, Hsp70 and CHIP that regulate the stability of different p53 mutant proteins improves the understanding of the pro-tumorigenic effects of increased HSp90 activity during multi-stage carcinogenesis.
Cross-Presentation of the Oncofetal Tumor Antigen 5T4 from Irradiated Prostate Cancer Cells—A Key Role for Heat-Shock Protein 70 and Receptor CD91
Josephine Salimu,Lisa Kate Spary,Saly Al-Taei,Aled Clayton,Malcolm David Mason,John Staffurth,Zsuzsanna Tabi +6 more
TL;DR: It is demonstrated that irradiation induces immunologically relevant changes in tumor cells, which can trigger CD8+ T-cell responses via a predominantly Hsp70-dependent antigen cross-presentation process.
17-ABAG, a novel geldanamycin derivative, inhibits LNCaP-cell proliferation through heat shock protein 90 inhibition
TL;DR: 17-ABAG inhibits the proliferation and induces apoptosis of LNCaP, an androgen-dependent prostate cancer cell line, in vitro through a classic apoptotic pathway and is demonstrated to be a promising anti-tumor agent.
Cooperative Regulation of the Interferon Regulatory Factor-1 Tumor Suppressor Protein by Core Components of the Molecular Chaperone Machinery
TL;DR: The role of the Mf1 domain of IRF-1 is elucidated in orchestrating the recruitment of regulatory factors that can impact on both its turnover and transcriptional activity.
The Heat Shock Protein 90-CDC37 Chaperone Complex Is Required for Signaling by Types I and II Interferons
TL;DR: It is demonstrated here that the inhibition of heat shock protein 90 (Hsp90) functions by small interfering RNAs or chemical inhibitors blocking interferon-induced gene expression, and it is concluded that JAK1/2 are client proteins of Hsp90 and that HSp90 and CDC37 play a critical role in types I and IIinterferon pathways.