Novel approach to cancer therapeutics using comparative cancer biology

TL;DR: It is suggested that Ran is required for and is a potential therapeutic target of Myc-driven cancer progression in both breast and lung cancers.

TL;DR: There is a white circle in Figure 6 that was erroneously introduced into a panel on the left side and the following link provides the correct version of Figure 6.

TL;DR: In this paper, a balance between stimulatory and inhibitory signals regulates the immune response to cancer, which contributes to immune resistance, especially against tumor antigen-specific T-cells.

TL;DR: Three promising Hsp90 inhibitors—retaspimycin, ganetespib, and NVP-AUY922—that are currently under evaluation either as monotherapy or in combination therapy for lung and breast cancers are focused on, and their potential relevance for future clinical practice is discussed.

TL;DR: Assessment of the impact of the tumor-mutated allele on structure-function relationship of the encoded protein and both loss- and gain-of-function of these genes and mutations on hepatoma cell behaviors in vitro provide evidence for supporting the validity of the proposed multi-omics strategy.

TL;DR: The cloning, sequence analysis and expression of the complete wildtype canine and equine mdm2 cDNAs are described to allow for the role of this oncogene to be established in companion animal oncology.

TL;DR: SOCS1 interference reduced the proliferation ability of Mel526 human melanoma cells and increased their sensitivity to IFN-γ.