Open AccessDissertation
Novel approach to cancer therapeutics using comparative cancer biology
Bhindu Revi
- 30 Jun 2018
4
About: The article was published on 30 Jun 2018. and is currently open access. The article focuses on the topics: Cancer & Ganetespib.
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Citations
Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition
Mikko Taipale,Irina Krykbaeva,Martina Koeva,Can Kayatekin,Kenneth D. Westover,Georgios I. Karras,Susan Lindquist,Susan Lindquist +7 more
- 01 Aug 2012
TL;DR: The results establish HSP90 client recognition as a combinatorial process: CDC37 provides recognition of the kinase family, whereas thermodynamic parameters determine client binding within the family.
31
RanGTPase : a candidate for myc-mediated cancer progression
Hiu-Fung Yuen,Vignesh Gunasekharan,Kai-Kumar Chan,Shu-Dong Zhang,Angela Platt-Higgins,Kathy Gately,Kenneth J. O'Byrne,Dean A. Fennell,Patrick G. Johnston,Philip S. Rudland,Mohamed El-Tanani +10 more
- 01 Jan 2013
TL;DR: It is suggested that Ran is required for and is a potential therapeutic target of Myc-driven cancer progression in both breast and lung cancers.
27
Correction: Molecular Mechanism of Mutant p53 Stabilization: The Role of HSP70 and MDM2
Milena Wiech,Maciej B. Olszewski,Zuzanna Tracz-Gaszewska,Bartosz Wawrzynow,Maciej Zylicz,Alicja Zylicz +5 more
TL;DR: There is a white circle in Figure 6 that was erroneously introduced into a panel on the left side and the following link provides the correct version of Figure 6.
16
Stimulating immune responses to fight cancer: Basic biology and mechanisms
Kenneth J. O'Byrne,Kenneth J. O'Byrne,Kenneth J. O'Byrne +2 more
- 01 Jan 2015
TL;DR: In this paper, a balance between stimulatory and inhibitory signals regulates the immune response to cancer, which contributes to immune resistance, especially against tumor antigen-specific T-cells.
3
References
Heat Shock Protein 90 Is Critical for Regulation of Phenotype and Functional Activity of Human T Lymphocytes and NK Cells
Jooeun Bae,Aditya Munshi,Cheng Li,Mehmet Kemal Samur,Rao Prabhala,Constantine S. Mitsiades,Kenneth C. Anderson,Nikhil C. Munshi +7 more
TL;DR: The need to closely monitor immune function in patients being treated with a Hsp90 inhibitor is demonstrated and may provide a potential therapeutic application in autoimmune diseases.
16
Correction: Molecular Mechanism of Mutant p53 Stabilization: The Role of HSP70 and MDM2
Milena Wiech,Maciej B. Olszewski,Zuzanna Tracz-Gaszewska,Bartosz Wawrzynow,Maciej Zylicz,Alicja Zylicz +5 more
TL;DR: There is a white circle in Figure 6 that was erroneously introduced into a panel on the left side and the following link provides the correct version of Figure 6.
16
Endoplasmic reticulum stress response and transcriptional reprogramming.
TL;DR: A collection of timely research and review articles with a focus on ER stress response and transcriptional reprogramming in health and disease are assembled.
Targeted therapy of soft tissue sarcomas.
TL;DR: Targeting the PI3 kinase/Akt pathway has been shown to be clinically promising in a diversity of different sarcoma subtypes, and inhibition of the vascular endothelial growth factor (VEGF)/VEGF receptor pathway is of special interest in vascular sarcomas subtypes.
15
Heat shock protein expression in canine osteosarcoma
Mariarita Romanucci,Giuliana D’Amato,Daniela Malatesta,Laura Bongiovanni,Chiara Palmieri,Andrea Ciccarelli,Paolo Buracco,Emanuela Maria Morello,L. Maniscalco,Raffaella De Maria,Marina Martano,Leonardo Della Salda +11 more
TL;DR: In this paper, the authors evaluated the immunohistochemical expression of Hsp27, Hsp72, HSP73 and Hsp90 in 18 samples of canine appendicular OSA, in relation to histological grade and overall survival.