NOVA: a software to analyze complexome profiling data.
Heiko Giese,Jörg Ackermann,Heinrich Heide,Lea Bleier,Stefan Dröse,Ilka Wittig,Ulrich Brandt,Ina Koch +7 more
TL;DR: Nova, a software for the analysis of complexome profiling data, supports the investigation of the composition of complexes, cluster analysis of the experimental data, visual inspection and comparison of experiments and many other features.
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Abstract: SUMMARY: We introduce nova, a software for the analysis of complexome profiling data nova supports the investigation of the composition of complexes, cluster analysis of the experimental data, visual inspection and comparison of experiments and many other features AVAILABILITY AND IMPLEMENTATION: nova is licensed under the Artistic License 20 It is freely available at http://wwwbioinformatikuni-frankfurtde nova requires at least Java 7 and runs under Linux, Microsoft Windows and Mac OS CONTACT: inakoch@bioinformatikuni-frankfurtde
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Citations
The Assembly Pathway of Mitochondrial Respiratory Chain Complex I.
Sergio Guerrero-Castillo,Sergio Guerrero-Castillo,Fabian Baertling,Fabian Baertling,Daniel Kownatzki,Hans J. C. T. Wessels,Susanne Arnold,Ulrich Brandt,Ulrich Brandt,Leo G.J. Nijtmans +9 more
TL;DR: A dynamic complexome profiling approach is applied to elucidate the assembly of human mitochondrial complex I and its further incorporation into respiratory chain supercomplexes, fully consistent with recent structural data and the remarkable modular architecture of this multiprotein complex.
388
Evolution and structural organization of the mitochondrial contact site (MICOS) complex and the mitochondrial intermembrane space bridging (MIB) complex.
Martijn A. Huynen,Mareike Mühlmeister,Katherina Gotthardt,Sergio Guerrero-Castillo,Sergio Guerrero-Castillo,Ulrich Brandt,Ulrich Brandt +6 more
TL;DR: In this article, the distribution of mitochondrial contact site and cristae organizing system (MICOS) complex proteins and mitochondrial intermembrane space bridging complex (MIB) proteins over sub-complexes and over species.
187
Membrane-bound electron transport systems of an anammox bacterium: A complexome analysis.
Naomi M. de Almeida,Hans J. C. T. Wessels,Rob M. de Graaf,Christina Ferousi,Mike S. M. Jetten,Jan T. Keltjens,Boran Kartal +6 more
TL;DR: The method of proteomics-based complexome profiling was applied to get a better understanding of the electron transport systems of the anaerobic ammonium-oxidizing (anammox) bacteria, the N2-producing key players of the global nitrogen cycle.
96
The assembly pathway of complex I in Arabidopsis thaliana
Joanna Ligas,Emmanuelle Pineau,Ralph Bock,Martijn A. Huynen,Etienne H. Meyer,Etienne H. Meyer +5 more
TL;DR: The assembly pathway of complex I in the model plant Arabidopsis thaliana is described and it is found that complex I assembly in plants follows a different, and likely ancestral, pathway compared with the one in humans.
93
Mitochondrial complexome reveals quality-control pathways of protein import
Uwe Schulte,Fabian den Brave,Alexander Haupt,Arushi Gupta,Jiyao Song,Catrin Swantje Müller,Jeannine Engelke,Swadha Mishra,Christoph U. Mårtensson,Lars Ellenrieder,Chantal Priesnitz,Sebastian P. Straub,Kim Nguyen Doan,Bogusz Kulawiak,Wolfgang Bildl,Heike Rampelt,Nils Wiedemann,Nikolaus Pfanner,Bernd Fakler,Thomas Becker +19 more
TL;DR: The MitCOM dataset as discussed by the authors is a high-resolution complexome profiling of more than 90% of the yeast mitochondrial proteome, termed MitCOM, which is a comprehensive resource for the identification, organization and interaction of mitochondrial machineries and pathways.
83
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