Journal Article10.1021/ACS.CHEMREV.6B00237
Nonclassical Routes for Amide Bond Formation
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TL;DR: The present review offers an overview of nonclassical (e.g., with no pre- or in situ activation of a carboxylic acid partner) approaches for the construction of amide bonds.
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Abstract: The present review offers an overview of nonclassical (e.g., with no pre- or in situ activation of a carboxylic acid partner) approaches for the construction of amide bonds. The review aims to comprehensively discuss relevant work, which was mainly done in the field in the last 20 years. Organization of the data follows a subdivision according to substrate classes: catalytic direct formation of amides from carboxylic and amines (section 2); the use of carboxylic acid surrogates (section 3); and the use of amine surrogates (section 4). The ligation strategies (NCL, Staudinger, KAHA, KATs, etc.) that could involve both carboxylic acid and amine surrogates are treated separately in section 5.
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Citations
Biocatalytic Amide Bond Formation
TL;DR: Amide bonds occur in over half of target compounds in medicinal chemistry patents, making amide bond formation the most commonly performed reaction in the pharmaceutical industry as mentioned in this paper . But amide bonds are difficult to synthesize.
A New Wave of Amide Bond Formations for Peptide Synthesis
TL;DR: In this article, a short review focuses on the advances made in these "non-classical" methods for amide bond formation with a specific application in peptide chemistry, and consists of two main sections: (i) novel carboxylic activation reagents, and (ii) carboxyl acid and amine surrogates.
Photoredox-Catalyzed Addition of Carbamoyl Radicals to Olefins: A 1,4-Dihydropyridine Approach
TL;DR: A photoredox‐catalyzed protocol for alkene carbamoylations with high levels of regio‐ and chemoselectivity is reported, which is reported to be the first of its kind in the world.
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An unsymmetrical covalent organic polymer for catalytic amide synthesis.
TL;DR: The first report on the Covalent Organic Polymer (COP) directed non-classical synthesis of an amide bond is presented and the practical utility of the present method is shown in the catalytic synthesis of paracetamol.
46
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Cell Surface Engineering by a Modified Staudinger Reaction
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