Journal Article10.1016/J.CLD.2004.04.014
Nonalcoholic Fatty Liver Disease
TL;DR: AASLD consensus guidelines require the presence of liver injury in the form of ballooning to distinguish NASH from other disorders of the NAFLD disease spectrum as discussed by the authors, which is defined by fat deposition in the liver in absence of secondary causes for steatosis.
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About: This article is published in Clinics in Liver Disease. The article was published on 01 Aug 2004. The article focuses on the topics: Fatty liver & Nonalcoholic fatty liver disease.
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Citations
Assessment of lipid, hepatic, and thyroid parameters with serum perfluorooctanoate (PFOA) concentrations in fluorochemical production workers
Geary W. Olsen,Larry R. Zobel +1 more
TL;DR: There was no evidence that employees’ serum PFOA concentrations were associated with total cholesterol or LDL, and several explanations are offered for the inconsistent triglyceride associations with PFO a including both methodological as well as biological possibilities.
The role of fatty acids in the development and progression of nonalcoholic fatty liver disease
TL;DR: Data suggest that saturated fatty acids may represent an intrinsic second hit to the liver that hastens the development of NASH.
Apoptosis is associated with CD36/fatty acid translocase upregulation in non-alcoholic steatohepatitis.
Lars P. Bechmann,Robert K. Gieseler,Jan-Peter Sowa,Alisan Kahraman,Jochen Erhard,Inga Wedemeyer,Barbara Emons,Christoph Jochum,Thorsten Feldkamp,Guido Gerken,Ali Canbay +10 more
TL;DR: The effect of obesity on free fatty acid levels, fatty acid transport proteins (FATPs) and on extrinsic and intrinsic activation of apoptosis in the liver is studied.
106
Nonalcoholic steatohepatitis (nash) with diabetes: predictors of liver fibrosis
Deepak Amarapurkar,Anjali D Amarapurkar,Nikhil Patel,Subhash Agal,R. Baigal,Parijat Gupte,Pramanik Ss +6 more
TL;DR: There is no definite noninvasive test that helps to predict liver fibrosis however AST, ALT levels and AST: ALT ratio may help to determine the fibrosis in patients of NASH with diabetes in majority of cases.
96
Alleviation of high-fat diet-induced fatty liver damage in group IVA phospholipase A2-knockout mice.
Hiromi,Naoki Yokoyama,Shintaro Yoshida,Kae Tsutsumi,Shinji Hatakeyama,Takashi Sato,Keiichi Ishihara,Satoshi Akiba +7 more
TL;DR: It is suggested that a deficiency of IVA-PLA2 alleviates fatty liver damage caused by high-fat diets, probably because of the lower generation of IV a phospholipase A2 metabolites, such as prostaglandin E2.
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Mariana Lagos-Quintana,Reinhard Rauhut,Abdullah Yalcin,Jutta Meyer,Winfried Lendeckel,Thomas Tuschl +5 more
TL;DR: 34 novel miRNAs were identified by tissue-specific cloning of approximately 21-nucleotide RNAs from mouse and a miRNA was identified that appears to be the fruitfly and mammalian ortholog of C. elegans lin-4 stRNA.
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