Journal Article10.1016/0306-4522(95)00578-1
Nitric oxide synthase and neuronal vulnerability in parkinson's disease
Stéphane Hunot,Florence Boissière,Baptiste Faucheux,Bernard Brugg,A. Mouatt-Prigent,Yves Agid,E. C. Hirsch +6 more
609
TL;DR: A potentially deleterious role of glial cells producing excessive levels of nitric oxide in Parkinson's disease, which may be neurotoxic for a subpopulation of dopaminergic neurons, especially those not expressing NADPH-diaphorase activity.
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About: This article is published in Neuroscience. The article was published on 01 May 1996. The article focuses on the topics: Nitric oxide synthase & Nitric oxide.
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Citations
Expression of endothelial and inducible NOS-isoforms is increased in Alzheimer's disease, in APP23 transgenic mice and after experimental brain lesion in rat : evidence for an induction by amyloid pathology
TL;DR: It is suggested that altered expression of these NOS isoforms being part of AD pathology is secondary to the amyloid pathology and might not be primarily involved in the pathogenetic chain though it might contribute to the maintenance, self-perpetuation and progression of the neurodegenerative process.
Nitric oxide synthase genes and their interactions with environmental factors in Parkinson’s disease
TL;DR: These data implicate NOS1 and NOS2A as genetic risk factors for PD and demonstrate that their interactions with established environmental factors may modulate the environmental effects.
Expression of neuronal nitric oxide synthase in the retina of a rat model of chronic glaucoma
TL;DR: The expression of neuronal nitric oxide synthase (nNOS) in a rat retina model of chronic glaucoma and double labeling of retinal ganglion cells revealed that RGCs in the retina of cauterized rat was nNOS-immunopositive suggest that the cytotoxicity of excessive NO plays a role in selective RGC loss in glauca.
The anti-inflammatory effect of Agaricus brasiliensis is partly due to its linoleic acid content.
TL;DR: This study found that linoleic acid isolated from A. brasiliensis inhibited NO production and suppressed the expression of pro-inflammatory cytokines including TNF-α, IL-6,IL-1β, and NOS2 in RAW 264.7 cells.
Neuroprotective role of aminoguanidine in behavioral changes after blast injury.
TL;DR: It is suggested that AG could play a neuroprotective role in rats subjected to blast exposure, and correlates well with histologic examination that showed a reduction in degenerating cortical neurons in AG-treated rats compared with those receiving saline injection.
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