Nitric oxide synthase activity in mitochondria
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TL;DR: The existence of a functional nitric oxide synthase (NOS) in rat liver mitochondria and its Ca2+ dependence are highly relevant for mitochondrial functioning are suggested.
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About: This article is published in FEBS Letters. The article was published on 01 Dec 1997. and is currently open access. The article focuses on the topics: Inner mitochondrial membrane & Nitric oxide.
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Citations
Role of the mitochondrial sodium/calcium exchanger in neuronal physiology and in the pathogenesis of neurological diseases.
Pasqualina Castaldo,Mauro Cataldi,Simona Magi,Vincenzo Lariccia,Sara Arcangeli,Salvatore Amoroso +5 more
TL;DR: Convincing experimental evidence suggests that supraphysiological activation of NCX(mito) contributes to neuronal cell death in the ischemic brain and, in epileptic neurons coping with seizure-induced ion overload, reduces the ability to reestablish normal ionic homeostasis.
Mitochondria in multiple sclerosis.
Pedram Ghafourifar,Kazem Mousavizadeh,Mordhwaj S. Parihar,Rafal R. Nazarewicz,Arti Parihar,Woineshet J. Zenebe +5 more
TL;DR: The present review summarizes critical role of mitochondria in the pathogenesis of MS and provides rationale for novel approaches to this disease and development of novel therapeutic maneuvers.
Activation of murine microglial cell lines by lipopolysaccharide and interferon-gamma causes NO-mediated decreases in mitochondrial and cellular function
David W. Moss,Timothy E. Bates +1 more
TL;DR: The observations demonstrate that induction of NOS activity in microglia results in damage to the plasma membrane leading to a loss of glutathione, complex‐specific inhibition of the mitochondrial electron transport chain and depletion of cellular ATP, and suggest that pharmacological modulation of Nos activity in activatedmicroglia in vivo may prevent cellular damage to bystander cells such as neurons, astrocytes and oligodendrocyts, as well as to microglias themselves.
Effects of rotenone and pyridaben on complex I electron transfer and on mitochondrial nitric oxide synthase functional activity.
TL;DR: Rotenone and pyridaben were tested on activities and properties of rat brain mitochondria determining Ki (inhibitor concentration at half maximal inhibition) and Imax (% of inhibition at maximal inhibitor concentration) and this fact is interpreted as an indication of mtNOS being structurally adjacent to complex I with an intermolecularmtNOS-complex I hydrophobic bonding that is stronger at high Δψ and weaker at low Δ ψ.
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TL;DR: The organophosphate nerve agent model of epilepsy and disease mitigation by saracatinib is characterized by the effects of OPNAs on females, cortical glial scars, and the efficacy of saracatinib in reducing gliosis and neurodegeneration.
References
•Journal Article
Nitric oxide: physiology, pathophysiology, and pharmacology
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The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide
TL;DR: The cage mechanism can explain the residual yield of nitrate that appears to be formed even in the presence of high concentrations of all of the scavengers studied to date, since scavengers capture only free HO. and .NO2 and not caged radicals.
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Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases.
M. W. J. Cleeter,JM Cooper,Victor M. Darley-Usmar,Salvador Moncada,Anthony H.V. Schapira,Anthony H.V. Schapira +5 more
TL;DR: Results indicate that nitric oxide is capable of rapidly and reversibly inhibiting the mitochondrial respiratory chain and may be implicated in the cytotoxic effects of Nitric oxide in the CNS and other tissues.
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Nitric oxide synthase: aspects concerning structure and catalysis.
TL;DR: It is assumed, given the monooxygenase-like activity of NOS and the heavy iso- tope labeling studies, that H20 is the ultimate fate of the other oxygen atom.
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